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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 February 2018 to 05 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 45.3 - <= 220.2 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 7 d
- Temp.:
- 20 °C
- pH:
- >= 7.77 - <= 9.22
- Remarks on result:
- other: Solubility was dependent on nominal concentration range of the test material in water and therefore no exact value was determined.
- Details on results:
- Measurements during Equilibration
- The carbon content of the test material (72.0 %) was used in the calculation of the test material concentration from the measured DOC concentration.
- After the analysis of the sample of day 7, the plateau was considered as reached.
Results
- The measurements on day 7 (flasks 1C and 2 – 5) were included in the calculation of the solubility of the test material in water.
- Linear dependency of solubility on amount of the test material (nominal load) was perceived in the main test 2.
- As solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. The solubility range for the tested nominal concentration 100 – 800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
Discussion
- The solubility of the test material in water was determined from the measured concentrations of DOC in the filtrated test solutions.
- Equilibration time can be considered as approx. 7 days. The measurements of flasks 1C and 2 – 5 were included in the calculation of the solubility of the test material in water. Flask 6 was considered as outlier because the measured DOC concentration using 1 000 mg/L nominal concentration was lower than in flask 5 with 800 mg/L nominal concentration.
- The Total carbon content of the test material was determined under non-GLP conditions in the laboratory Mikroanalytisches Labor Pascher (53424 Remagen, Germany) with 72.00 % and the value was used in the calculation of the test material concentration from the measured DOC concentration.
- As solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. The solubility range for the tested nominal concentration 100-800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
- No observations arousing doubts concerning the accuracy of the results and the validity of the study were made. - Conclusions:
- Under the conditions of this study, as solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. The solubility range for the tested nominal concentration 100-800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions.
The solubility of the test material in water was determined by measurement of dissolved organic carbon (DOC) concentration in the filtrated test solutions using total organic carbon (TOC) analyser. The total carbon (TC) content of the test material 72.00 % was used in the calculation of the test material concentration from the measured DOC concentration.
Six different loading rates of the test material were chosen to study the effect of the loading rate on the measured water solubility: 100, 300, 600, 800, 1 000 mg/L. Three flasks 1A - C with the same loading rate (500 mg/L) were used during equilibration.
Equilibration was monitored by measurements of flasks 1A - C. Due to a difference of less than 15 % in the concentrations on days 6 and 7 and no upward tendency in the last three time points, the final measurement was performed on day 7 as determination from flasks 2 – 6. DOC was measured via TOC analyser in the saturated aqueous solutions.
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles were present.
Under the conditions of this study, as solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. At the plateau the solubility range for the tested nominal concentration 100-800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
Reference
Table 1: Equilibration
Day |
Temperature (°C) |
pH* |
Measured Values DOC (mg/L) |
Concentration Test Material (mg/L) |
Difference (%) |
1 |
20.0 |
6-7 |
74.24 |
103.1 |
- |
2 |
20.0 |
6-7 |
108.1 |
150.2 |
+ 45.7 |
3 |
20.0 |
6-7 |
116.2 |
161.4 |
+ 7.4 |
3 (blank) |
20.0 |
7 |
0.5 |
- |
- |
4 |
19.5 |
6-7 |
84.5 |
117.4 |
n.a. |
4 |
19.5 |
6-7 |
92.0 |
127.8 |
- 20.8 |
5 |
19.5 |
6-7 |
93.8 |
130.3 |
+ 1.9 |
6 |
19.5 |
6-7 |
100.1 |
139.1 |
+ 6.7 |
7 |
19.5 |
6-7 |
87.0 |
120.9 |
- 13.1 |
Values in italics (day 4): Measurement was repeated because the difference to day 3 appeared too large. Only the second measurement was used for evaluation Difference [%] is not applicable (n.a.).
* Measured via pH paper.
Table 2: Measurements at Plateau
Flask |
Temperature (°C) |
pH* |
Measured Values DOC (mg/L) |
Concentration Test Material (mg/L) |
Dissolved Part (%) |
2 |
20.5 |
7.77 |
32.6 |
45.3 |
45.3 |
3 |
20.5 |
8.79 |
82.4 |
114.4 |
38.1 |
4 |
20.5 |
9.22 |
116.2 |
161.3 |
26.9 |
5 |
20.5 |
9.09 |
158.5 |
220.2 |
27.5 |
6 |
20.5 |
8.48 |
141.1 |
196.0 |
19.6 |
* Measured via calibrated pH meter.
Table 3: Measurements Used for Calculation of Solubility
Flask |
Measured Concentration of Test Material (mg/L) |
Nominal Concentration of Test Material (mg/L) |
Dissolved Part (%) |
2 |
453 |
100 |
45.3 |
3 |
114.4 |
300 |
38.1 |
1C |
120.9 |
500 |
24.2 |
4 |
161.3 |
600 |
26.9 |
5 |
220.2 |
800 |
27.5 |
6* |
196.0 |
1 000 |
19.6 |
*Was considered as outlier and rejected for evaluation because the test material concentration was lower than in flask 5 with lower nominal concentration.
Description of key information
Under the conditions of this study, as solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. The solubility range for the tested nominal concentration 100-800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
Key value for chemical safety assessment
- Water solubility:
- 45.3 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The solubility of the test material in water was determined by measurement of dissolved organic carbon (DOC) concentration in the filtrated test solutions using total organic carbon (TOC) analyser. The total carbon (TC) content of the test material 72.00 % was used in the calculation of the test material concentration from the measured DOC concentration.
Six different loading rates of the test material were chosen to study the effect of the loading rate on the measured water solubility: 100, 300, 600, 800, 1 000 mg/L. Three flasks 1A - C with the same loading rate (500 mg/L) were used during equilibration.
Equilibration was monitored by measurements of flasks 1A - C. Due to a difference of less than 15 % in the concentrations on days 6 and 7 and no upward tendency in the last three time points, the final measurement was performed on day 7 as determination from flasks 2 – 6. DOC was measured via TOC analyser in the saturated aqueous solutions.
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles were present.
Under the conditions of this study, as solubility was dependent on nominal concentration, no exact value for the solubility of the test material in water can be stated. At the plateau the solubility range for the tested nominal concentration 100-800 mg/L is 45.3 – 220.2 mg/L, 20 ± 0.5 °C (45.3 – 220.2 * 10^-3 kg/m^3 in SI units), corresponding to 24.2 – 45.3 % of the test material relating to the nominal concentration of the test material.
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