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Diss Factsheets
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EC number: 224-583-8 | CAS number: 4419-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
one study on acute toxicity by oral route and one study on acute toxicity by inhalative route available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- unknown
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Only abstract with species and LD50 value given.
A handwritten report is available, language japanese - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- not available
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not available
- Doses:
- not available
- No. of animals per sex per dose:
- not available
- Control animals:
- not specified
- Details on study design:
- not available
- Statistics:
- not available
- Preliminary study:
- not available
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 6 000 mg/kg bw
- Mortality:
- description not available
- Clinical signs:
- other: description not available
- Gross pathology:
- description not available
- Other findings:
- description not available
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An LD50 (orally in mice) is available, it is stated to be over 6000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Quarantine and Animal Selection
were quarantined after arrival for 6 days prior to testing. During the quarantine period rats
were weighed and observed for clinical signs of disease 3 times. Rats were obtained from the
general population of stock rats released from quarantine and were selected for use on this study fiom those rats exhibiting a normal pattern of weight gain and no overt signs of disease.
Housing
Rats were housed either singly or in pairs in suspended, stainless steel, wire-mesh cages.
Animal Room Environment
Animal rooms were maintained on a timer-controlled, 12-hour light/12-hour dark cycle.
Environmental conditions of the rooms were targeted to be within a temperature range of 23 +/- 1°C and a relative humidity range d 50 +/-10%. Excursions outside these ranges were of insufficient magnitude and/or duration to have adversely affected the validity of the study.
Identification
IEach rat was assigned a unique 6-digit identification number which corresponded to a numbered card affixed to the cage. Prior to exposure, the tail of each rat was numbered with waterinsoluble markers so that individual rats could be identified after exposure.
Feed and Water
Exkept during exposure, PMI Feeds. Lnc. Certified Rodent Diet #5002 and tap water fromUnited Water Delaware were available ad libitum. - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 4.5 µm
- Geometric standard deviation (GSD):
- 2.2
- Details on inhalation exposure:
- Atmosphere Generation
Chamber atmospheres of the substance were generated by suspending the particulate test substance in
tered into the jetmill with a K-Tron model T-20 Twin Screw Volumetric Feeder. Filtered,
high-pressure air (60 Umin) introduced into the jetmill carried the resulting atmosphere into the exposure chamber. Chamber concentrations of the substance were controlled by varying the test.
Test atmospheres were exhausted through a high-capacity particle filter followed by an MSA charcoal/HEPA filter cartridge prior to discharge into the fume
hood.
Chamber Construction and Design
The exposure chamber was constructed of glass with a nominal internal volume of 34 L. A b fle positioned immediately inside the chamber inlet promoted
uniform chamber distribution ofthe test atmosphere.
Exposure Mode
During exposure, rats were individually restrained in stainless steel cylinders with conical nose pieces. The restrainers were inserted into the polymethylmethacrylate faceplate of the exposure chamber so that only the nose of each rat extended into the chamber. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 9.3 mg/L
Range: 6.8-15 mg/L3 (SD:3.2, n=6) - No. of animals per sex per dose:
- 6
- Control animals:
- no
- Key result
- Sex:
- male
- Dose descriptor:
- other: ALC
- Remarks:
- Approximate Lethal Concentration
- Effect level:
- 9.3 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- One rat died during exposure to H-22860 at a concentration of 9.3 mgL.
All remaining animals survived the exposure and were sacrificed at the conclusion of the I4-day recovery period. - Clinical signs:
- other: After the exposure, when the rats were removed from the restrainers. clinical signs included nasal and ocular discharges and stained and/or wet fur. In addition rats had test substance on their faces. These clinical signs are typically observed in rats su
- Body weight:
- Four of 5 surviving rats experienced slight to servere weight losses (ranging from I .8 to 15% of initial body weight ) within 1 day of exposure.
The I remaining rat gained weight. Body weights of rats began to increase by study day 3 and increased over the remainder of the 14day recovery period. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the approximate lethal concentration (ALC)for the substance is 9.3 mg/L. On an acute inhalation basis. The substance is considered to have very low toxicity (ALC greater tban 2 mg/L).
- Executive summary:
One group of 6 d e Cd:CD@(SD)BR rats was exposed nose-only for a single, 4-how period to the substance in air. The test atmosphere was generated by suspending the dry powder in air. The concentration of the substance
was determined by gravimetric analysis. Rats were weighed and observed far clinical signs of toxicity during a 14-day recovery period. Rats were exposed to a chamber concentration of 9.3 mg/L
the substance.
The mass median aerodynamic diameter (MMAD) of the dust generated was 4.5 pm. One rat died during the exposure to
the substance.
With the exception of 1 rat with hunched posture the day after exposure, no notable clinical signs of toxicity were evident on this study. Rats generally exhibited slight to severe body-weight losses within 1 day of exposure but began to regain weight by test day 3.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 9.3 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The available information is conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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