Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 410-610-2 | CAS number: 111850-24-9 MORTRACE SB CONC.
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 225
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 88 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- According to ECHA Guidance example R.8-2
- AF for dose response relationship:
- 3
- Justification:
- LOAEL to NOAEL extrapolation
- AF for differences in duration of exposure:
- 6
- Justification:
- subchronic to chronic default factor
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- already included in route to route extrapolation
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor
- AF for intraspecies differences:
- 5
- Justification:
- default factor for workers
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
The relevant toxicity endpoints for worker risk assessment are skin sensitisation for dermal exposures (qualitative assessment), and systemic toxicity via the inhalation route (quantitative assessment). Due to the skin sensitisation effect, dermal exposures will generally be minimised by RMM, so that a quantitative assessment of acute or repeated dose systemic or local exposures is not relevant. For the sake of simplicity, sytemic exposure via the inhalation route will for all exposure durations be assessed against the long term DNEL.
When deriving the Inhalation DNEL it has been assumed that oral and Inhalation bioavailability are the same. However as indicated in the toxicokinetics section and the summary of repeated dose toxicity data, this substance is estimated to be very poorly absorbed via all routes prior to the reduction of the azo bond. Once this occurs, the metabolites will be significantly more bioavailable via oral and dermal routes. Via inhalation the reduction of the azo bond is considered highly unlikely, consequently, the actual difference in absorption between these two routes (oral and inhalation) is considered to be closer to 100 fold. Therefore due to potential differences in metabolism the oral toxicity studies may not be completely representative of an inhalation hazard (likely an over vast estimate).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Concentrations in consumer products (fuel) will be below 0.01%, hence no assessment is warranted
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
