Registration Dossier
Registration Dossier
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EC number: 439-210-6 | CAS number: 554-62-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 62630012
- Expiration date of the lot/batch: 01.11.2002
- Purity: 94.0 %
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature in the dark - Key result
- Water solubility:
- >= 0.001 - <= 0.004 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.5 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 8.5
- Remarks on result:
- completely miscible
- Conclusions:
- In conclusion, the water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/I, using the column elution method. The geometric mean is 2.6 mg/L.
- Executive summary:
The column elution method was used to determine the water solubility of Phytosphingosine and was based on the following guidelines:
OECD guideline for testing of chemicals no. 105: "Water Solubility", Adopted July 27, 1995. EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992. Several attempts were made to determine the water solubility of Phytosphingosine accurately. The results are shown in the table.
Column Actual flow rate [ml/h] Mean [mg/l] pH I 24.0 3.67 8.3 12.0 3.81 8.3 II 24.0 1.36 8.5
12.0 2.40 8.5 III 24.3 2.14 7.6 12.0 2.07 7.8 IV 24.0 2.19 7.7 11.9 2.11 7.8 V 24.3 3.28 6.4 12.0 3.25 7.0 24.6 3.22 6.6 VI 12.0 3.07 7.1 Based on these results it was decided to report water solubility of Phytosphingosine to be between 1.4x10^-3 and 3.8x10^-3 g/1 at 20.0 ± 1.0°C.
Reference
Description of key information
The water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/L, using the column elution method. The geometric mean is 2.6 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 2.6 mg/L
- at the temperature of:
- 20 °C
Additional information
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