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Diss Factsheets
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EC number: 944-490-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- This deviation was not considered to have compromised the validity or integrity of the study.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-hydroxyoctan-2-yl octadeca-9,12,15-trienoate; 2-hydroxyoctyl octadeca-9,12,15-trienoate; 2-hydroxyoctyl octadeca-9,12-dienoate; octane-1,2-diol
- EC Number:
- 944-490-2
- Molecular formula:
- unknown
- IUPAC Name:
- 1-hydroxyoctan-2-yl octadeca-9,12,15-trienoate; 2-hydroxyoctyl octadeca-9,12,15-trienoate; 2-hydroxyoctyl octadeca-9,12-dienoate; octane-1,2-diol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Pale yellow oily liquid.
Density of 0.95.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 6 nulliparous and non pregnant female rats, aged 8 or 9 weeks at the time of dosing.
Acclimatation period of at least 5 days before dosing: animals were observed once a day for clinical signs and mortality.
Temperature of 22°C, hydrometry between 30 and 70%, at least 10 full air changes/h, 12h/12h light/dark cycle (7 a.m. to 7 p.m.). Food and drink given ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Administration by gavage, using a plastic syringe fitted with an esophageal canula.
- Doses:
- 2000 mg/kg as starting dose.
The starting dose-level was selected considering the chemical structure of the test item (ester of unsaturated fatty acid and alcohol in C8) which is not expected to induce mortality at 2000 mg/kg when administered by the oral route. - No. of animals per sex per dose:
- 3 animals/step (maximum of 2 steps per dose-level)
- Control animals:
- not specified
- Details on study design:
- The test item was tested using a stepwise procedure with a maximum of 2 steps per dose-level. The starting dose was fixed at 2000 mg/kg (two steps) with a dosage-volume of 2.1 mL/kg which corresponded to the liquid form of the test item.
Administration of treatment to rats followed by 14 or 15 days of observation. Body weights were measured on days 1, 3, 8 and 15 and macroscopic examination was performed for all sacrificed animals on day 15. Clinical signs were assessed 30 min, 1h and 3h after dosing and then, once daily for 14 days. Mortality and morbidity checks were carried out twice on day 1 then once daily. - Statistics:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 2000 mg/kg, no death were observed at either step throughout the period of observation.
- Clinical signs:
- other: At 2000 mg/kg, no clinical signs were observed throughout the period of observation.
- Gross pathology:
- No anomaly was detected at necropsy.
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Within the experimental conditions of the study, Diolénique C8, can be assigned to Category 5 or the Unclassified Category of the GHS. Since no mortality was encountered, the LD50 is estimated to be higher than 2500 mg/kg.
- Executive summary:
In an OECD Guideline N° 423 Acute Oral Toxicity test, Diolénique C8 can be assigned to Category 5 or the Unclassified Category of the GHS. Since no mortality was encountered, the LD50 is estimated to be higher than 2500 mg/kg.
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