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EC number: 619-946-6 | CAS number: 890707-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2011 - May 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Amino-5-cyano-N,3-dimethylbenzamide
- Cas Number:
- 890707-29-6
- Molecular formula:
- C10H11N3O
- IUPAC Name:
- 2-Amino-5-cyano-N,3-dimethylbenzamide
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil: 10 g mixture of fine ground quartz sand and 55 mg test substance were mixed with 740 g wet artificial soil for each test container to form 100 mg/kg dry soil test substance systems.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworm
- Age at test initiation: 2-3 months
- Weight at test initiation: 308-352 mg
ACCLIMATION
- Acclimation period: 7 d
- Acclimation conditions: same as test
- Health during acclimation: Healthy, no mortality observed
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 17.4-21.1°C
- pH:
- 6.99-7.03
- Moisture:
- 20-30%
- Details on test conditions:
- TEST SYSTEM
- Test container: Test containers were covered with perforated plastic film to prevent test medium from drying
- Amount of soil or substrate: 740 g wet artificial soil/test container
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Composition: sphagnum peat 10%, kaolin clay 20%, industrial sand 70%
OTHER TEST CONDITIONS
- Photoperiod: Continuos light
- Light intensity: 400-800 Lux
EFFECT PARAMETERS MEASURED: Mortality observed at day 7 and 14. Total wight of earthworms were determined at beginning and end of test.
TEST CONCENTRATIONS
- Range finding study: yes
- Test concentrations: 1, 10, 100 and 1000 mg/kg dry soil
- Results used to determine the conditions for the definitive study: The modified mortality in the 7-d range finding study was 5.3%, 0.0%, 0.0% and 15.8% respectively for the test groups. - Nominal and measured concentrations:
- Nominal concentration: 100 mg/kg dry soil
- Reference substance (positive control):
- yes
- Remarks:
- Chloracetamide
Results and discussion
Effect concentrations
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: No mortality was observed in the control group. Mortality in test substance group (100 mg/kg dry soil): 1/40 earthworms.
- Results with reference substance (positive control):
- The mortality in the controls did not exceed 10%. The mortality in the test groups (10, 20, 40, 80 and 160 mg/kg) were 5%, 62.5%, 100%, 100% and 100% respectively. The 14d-LC50 of chloracetamide was 18.2 mg/kg dry soil.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the test, the 14d-LC50 of the test substance to Eisenia fetida was greater than 100 mg/kg dry soil
- Executive summary:
The acute toxicity of the test substance to Eisenia fetida was determined in a 14 days artificial soil test according to OECD guideline 207.
The test was conducted as a limit test at a nominal concentration of 100 mg/kg dry artificial soil. The number of mortalities were determined after 7 and 14 days exposure. The mortality of the earthworms in the blank control group was 0% and the test is evaluated as valid.
Under the conditions of the test, the 14d-LC50 of the test substance to Eisenia fetida was greater than 100 mg/kg dry soil.
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