Registration Dossier
Registration Dossier
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EC number: 226-952-9 | CAS number: 5577-13-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP. Guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- EC Number:
- 226-952-9
- EC Name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- Cas Number:
- 5577-13-9
- Molecular formula:
- C10H13NO4S
- IUPAC Name:
- ethyl [(4-methylphenyl)sulfonyl]carbamate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Each strain derived from Salmonella typhimuriun LT2 contains one mutation in the histidine operon, resulting in a requirement for histidine. In adittion, to increase their sensitivity to mutagenic substance, further mutations have been added.
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Test concentrations with justification for top dose:
- Range: 125 - 5000 µg/plate
- Details on test system and experimental conditions:
- The day before treatment, cultures, will be inoculated from froz
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Genotoxicity:
- other: No increase in the nobody of revertants.
- Cytotoxicity / choice of top concentrations:
- other: Any other information on results incl. tables
- Vehicle controls validity:
- other: each bacterial tester strain treated with the vehicle
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Under the experimental conditions, the test substance Tolfamato did not show any mutagenic activity in this bacterial reverse mutation test on Salmonella typhimurium.
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions, the test substance Tolfamato did not show any mutagenic activity in this bacterial reverse mutation test on Salmonella typhimurium.
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