Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-401-6 | CAS number: 10141-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- As with all inorganic salts, the significance for toxicity or environmental assessment, is the presence of specific ions that will form when in solution or when in biological systems.In the case of Cr III salts, the counter ion will have an effect on solubility and this is itself dependant on the type of media being used and in particular the pH of that media. It is generally accepted that in the case of metal salts, testing with salts that are soluble in the respective test media will ensure maximum exposure of the metal ions. This will include chlorides and nitrates as being more soluble and will indeed have relevance when dissolved in acid media, such as if ingested.Read-across to other chromium III salts is therefore considered valid as long as the exposure in the test system is greater than would be expected for the substance under review for registration.
Data source
Reference
- Reference Type:
- publication
- Title:
- SENSITIZATION OF GUINEA PIGS TO CHROMIUM SALTS
- Author:
- PAUL R. GROSS, SIDNEY A. KATZ, M.H. SAMITZ
- Year:
- 1 968
- Bibliographic source:
- THE JOURNAL OF INVESTIGATIVE DERMATOLOGY - VOL. 50 424-427
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- THE PURPOSE OF THE METHODS WAS TO EXAMINE CROSS SENSITISATION BETWEEN Cr(VI) to Cr(III). THE TEST METHOD WAS MODIFIED TO PROVIDE A CONSISTENTLY SUCCESSFUL LEVEL OF SENSITIZATION.
- GLP compliance:
- no
- Remarks:
- BEFORE GLP
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- EXISTING DATA, FURTHER ANIMAL STUDIES NOT JUSTIFIED
Test material
- Reference substance name:
- Chromium trichloride
- EC Number:
- 233-038-3
- EC Name:
- Chromium trichloride
- Cas Number:
- 10025-73-7
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino guinea pig
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- other: Freud's complete adjuvant
- Concentration / amount:
- 0,5 cc of 3,4e-2M CrCl3
Challenge
- Route:
- intradermal
- Vehicle:
- other: Freund's complete adjuvant
- Concentration / amount:
- 0,1 cc of 4.2e+4M Cr Cl3
- No. of animals per dose:
- 30
- Details on study design:
- Guinea pigs were sensitised by administering three subcutaneous injections of an emulsion containing 0.5 cc Freund's complete adjucant and 0,5 cc 3.4 x 10-2 M CrCl3 into the nape one week apart. Three weeks later, the animals were tested with intradermal injections in clipped or epilated skin. The eliciting dose was 4.2 x 10-4 M CrCl3. Animals sensitised with CrCl3 were also tested with a number of additional trivalent salts, and to conjugates of chromium linked with plasma proteins and skin extract proteins. The concentrations were determined as being the lowest concentrations causing positive effects with Chrome VI compounds.
- Challenge controls:
- The challenge dose produced no reaction in 30 control animals.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 66 mg/l
- No. with + reactions:
- 0
- Total no. in group:
- 30
- Clinical observations:
- No adverse effects
- Remarks on result:
- no indication of skin sensitisation
- Group:
- negative control
- Remarks on result:
- not determinable because of methodological limitations
- Group:
- positive control
- Remarks on result:
- not determinable because of methodological limitations
Applicant's summary and conclusion
- Interpretation of results:
- other: See the publication attached
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.