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Diss Factsheets
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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Laboratory-cultured fathead minnows 1-2 months old were used; they averaged 0.27 g and 28 mm total length. They were not fed 48 hours before the test, and during this time they were acclimated to the test temperature of 20 +-0.5°C. The test vessels were 7.6 -liter aquaria covered with aluminum foil; each aquarium contained 6 liters of test solution and five fish. Two aquaria were used for each of the three or four test concentrations. The fish were not fed and the solutions were not aerated or changed during the 96 -hour tests. The toxicant concentration, DO, and pH were measured at 0, 24, 48, 72, and 96 hours of each test. The number of surviving animals were recorded at these times, and at hours 2 and 16 of the test. The criterion of toxic effect was defined as complete immobilization, which is equated with death.
- GLP compliance:
- not specified
- Vehicle:
- yes
- Remarks:
- water
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- laboratory-cultured fathead minnows 1-2 months old
- Test type:
- static
- Water media type:
- freshwater
- Hardness:
- 140 mg/L CaCO3
- Test temperature:
- 20°C (+- 0,5°C)
- pH:
- 7,8
- Dissolved oxygen:
- 8,5 mg/L (time zero) to 4,3 mg/L (48 h later)
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.46 mg/L
- Basis for effect:
- mortality (fish)
- Details on results:
- 95% fiducial limits: 2.43- 3.90 mg/L
- Reported statistics and error estimates:
- For all tests except those with algae, the data were corrected for the control response by Abbott's (1925) formula. Because the proportion of algae that responded in the test concentrations could not be determined, the responses were expressed as a percent of the control response.
All LC50s and EC50s were estimated by probit analysis (Finney 1978). - Conclusions:
- In a study of comparative acute toxicity to aquatic organisms, the LC50 of 2-naphthol for fathead minnows was calculated to 3,46 mg/L.
- Executive summary:
In a study of comparative acute toxicity to aquatic organisms, the LC50 of 2-naphthol for fathead minnows was calculated to 3,46 mg/L.
Reference
Description of key information
A short term toxicity study of 2-naphthol to fish was determined by Millemann et al.
No test guidelines were used but the study was well documented, met the generally accepted scientific principles and was deemed acceptable for assessment.
The species was laboratory-cultured fathead minnows (Pimephales promelas) 1-2 months old.
They were not fed 48 hours before the test, and during this time they were acclimated to the test temperature of 20 plus or minus 0.5 oC. The test vessels were 7.6 litre aquaria covered with aluminum foil; each aquarium contained 6 liters of test solution and five fish. Two aquaria were used for each of the three or four test concentrations. The fish were not fed and the solutions were not aerated or changed during the 96 -hour tests. The toxicant concentration, DO, and pH were measured at 0, 24, 48, 72, and 96 hours of each test. The number of surviving animals were recorded at these times, and at hours 2 and 16 of the test. The criterion of toxic effect was defined as complete immobilization, which is equated with death.
For all tests except those with algae, the data were corrected for the control response by Abbott's (1925) formula. Because the proportion of algae that responded in the test concentrations could not be determined, the responses were expressed as a percent of the control response.
All LC50s and EC50s were estimated by probit analysis (Finney 1978).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.46 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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