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EC number: 277-146-9 | CAS number: 72968-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin irritation: none
eye irritation: slight
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Principles of method if other than guideline:
- according to § 1500.41 in Federal Register Vol. 38, No. 187, S. 26019 ov 27.09.73
The procedure followed the standards of that time. - GLP compliance:
- no
- Specific details on test material used for the study:
- Name of test substance given in report: Thermoplastrot BS – Misch-Nr. 07-4264,
Composition given in report: 103,0 Teile Thermoplastrot Lm Fw/400 Stück ber. 100% - Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- breeder: M. Gaukler, 6050 Offenbach
mean weight: about 3.0 kg - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: pasted with 50% water
- Amount / concentration applied:
- about 0.5 g on a patch of about 2.5 x 2.5 cm
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- up to 8 days after patch removal
- Number of animals:
- 6 males
- Details on study design:
- TEST SITE
- Area of exposure: about 2.5 x 2.5 cm
- Type of wrap if used: patch is covered with a rubberized linnen lobe, fixed and wrapped with a gauze bandage
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days)
24 hours, 72 hours and 8 days after patch removal
SCORING SYSTEM:
- Method of calculation: scores of 1-4 for reddening and oedema - Irritation parameter:
- erythema score
- Basis:
- animal: 1-6
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- due to substance induced staining of the skin
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-6
- Time point:
- other: 72h and 8 days after patch removal
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: 1-6
- Time point:
- other: 24h, 72 h and 8 days after patch removal
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Executive summary:
In a skin irritation study performed according to Fed. Reg. 38, no. 187, § 1500.41 (1973) 0.5g of the solid test item pasted with water was applied for 24 hours to the intact skin of the back of 6 rabbits. 24 hour after patch removal erythema could not be evaluated due to a distinct red/brown staining of the skin due to the coloured test item. 72 hours and 8 days after patch removal no indication of erythema was recorded. Oedema was not seen at all scoring times (24h, 72h, 8days). The test item thus did not show irritating effects to the skin of rabbits.
Reference
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- according to Federal Register, Vol. 38, no. 187 (27.09.1973), § 1500.42 and Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, FDA, Austin, Texas 1959, p. 51
The procedure followed the standards of that time. - GLP compliance:
- no
- Specific details on test material used for the study:
- Name of test substance given in the report: Thermoplastrot BS – Misch-Nr. 07-4264
composition of test substance given in the report: 103,0 Teile Thermoplastrot Lm Fw/400 Stück ber. 100% - Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- breeder: M. Gaukler, 6050 Offenbach, Germany
mean weight: 2.9 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- amount of test item applied is not given in the report; after treatment the eye was tightly kept close
- Observation period (in vivo):
- 24, 48, and 72 hours
- Number of animals or in vitro replicates:
- 6 animals (1 male, 5 females)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1, 3, 4, 5, 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks:
- at time point 24h all animals showed score 1.0; at 48h 5 animals showed score 1.0 and one animal showed 2.0; at 72h 4 animals showed score 1.0 and 2 animals showed no effects
- Irritation parameter:
- chemosis score
- Basis:
- animal: 2, 3, 4, 5
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Other effects:
- slight lacrimation in some animals 24 and 48h after treatment
- Executive summary:
In an eye irritation study performed according to Fed. Reg. 38, no. 187, § 1500.42 (1973) in 1978 the solid test item was applied to the conjunctival sac of one eye of 6 rabbits. The other eye of each animal served as untreated control. The test item led to slight reddening of the conjunctivae in all animals 24 and 48h after treatment and in 4 animals at the time point 72 hours. Slight cornea effects were seen in one animal only at 24 hours and slight chemosis in 4 animals at 24 hours only. In conclusion, the test item led to slight eye irritation in this test.
Reference
Additional information
In a skin irritation study performed according to Fed. Reg. 38, no. 187, § 1500.41 (1973) in 1978 the solid test item pasted with water was applied for 24 hours to the intact skin of the back of 6 rabbits. 24 hour after patch removal erythema could not be evaluated due to a distinct red/brown staining of the skin due to the coloured test item. 72 hours and 8 days after patch removal no indication of erythema was recorded. Oedema was not seen at all scoring times (24h, 72h, 8days). The test item thus did not show irritating effects to the skin of rabbits.
In an eye irritation study performed according to Fed. Reg. 38, no. 187, § 1500.42 (1973) in 1978 the solid test item was applied to the conjunctival sac of one eye of 6 rabbits. The other eye of each animal served as untreated control. The test item led to slight reddening of the conjunctivae in all animals 24 and 48h after treatment and in 4 animals at the time point 72 hours. Slight cornea effects were seen in one animal only at 24 hours and slight chemosis in 4 animals at 24 hours only. In conclusion, the test item led to slight eye irritation in this test.
Justification for classification or non-classification
The substance showed no irritation on rabbit's skin and slight irritation to rabbit's eyes. Thus, no classification is warranted for skin and eye irritation.
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