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EC number: 261-919-2 | CAS number: 59766-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May 2012 - 29 August 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 24 February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- August 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF), 12 Nousan, Notification No 8147
- Version / remarks:
- November 2000; including the most recent partial revisions.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dipotassium titanate(2-)
- EC Number:
- 261-919-2
- EC Name:
- Dipotassium titanate(2-)
- Cas Number:
- 59766-31-3
- Molecular formula:
- K2O17Ti8
- IUPAC Name:
- dipotassium titanate(2-)
- Test material form:
- solid: particulate/powder
- Details on test material:
- Appearance: White powder
Storage conditions: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (Crl:CD 'SD')
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Charles River (UK) Ltd.
- Age at study initiation: Young adult animals (approx. 8-12 weeks old)
- Weight at study initiation: 362-403 g for males, 230-239 for females.
- Housing: Animals were housed individually from Day -1 until Day 4 when they were returned to group housing (in groups of five rats of the same sex).
- Diet: Free access to pelleted rodent diet (Rat and Mouse No. 1 Maintenance Diet).
- Water: Free access to tap water.
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 – \23
- Humidity (%): 40 - 70
- Air changes (per hr): Not indicated
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 21 June 2012 to 11 July 2012
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- One day before exposure (Day -1) the treatment on the dorso-lumbar region of the animal was clipped, exposing an area equivalent to approximately 10% of the total body surface area.
The test substance was applied by spreading it evenly over the prepared skin. The treatment area (approximately 50 mm x 50 mm) was covered with porous gauze held in place with a non-irritating dressing, and further covered by a waterproof dressing encircled firmly around the trunk of the animal.
Frequency: Single dosage, on Day 1.
Washing: Following application, dressings were removed and the skin cleaned of residual test substance using tap water. - Duration of exposure:
- 24 hours.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Dose volume: 4 mL/kg bw.
DOSAGE PREPARATION: The test substance was formulated at a concentration of 500 mg/mL in the vehicle
Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Mortality/Viability: Twice daily
Body weights: Days 1 (prior to dosing), 8 and 15.
Clinical signs: At periodic intervals on the day of dosing (day 1) and once daily thereafter, until day 15.
- Necropsy of survivors performed: All animals were subject to a macroscopic examination
- Other examinations performed: none. - Statistics:
- None.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- There were no clinical signs noted during the study.
- Body weight:
- A low bodyweight gain was noted for one female (F8) on Day 8. All other animals were considered to have achieved satisfactory bodyweight gains throughout the study.
- Gross pathology:
- No abnormalities were noted in any animal at the macroscopic examination.
- Other findings:
- No dermal reactions were observed in any animal during the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- according to Regulation (EC) 1272/2008
- Conclusions:
- In an acute dermal toxicity study with rats, performed according to the OECD 402 test guideline, an LD50 >2000 mg/kg bw was determined.
- Executive summary:
An acute dermal toxicity study in rats was performed according to the OECD 402 test guideline and in accordance with GLP principles. A group of 10 CD rats (5 males, 5 females) received a single topical application of the test substance, formulated in purified water, at a dose level of 2000 mg/kg bw, for the duration of 24 hours. There were no deaths during the study and no dermal reactions were observed. There were no effects found on bodyweight except for a low bodyweight in one female on day 8. No abnormalities were noted in any animal at the macroscopic examination. The LD50 value of TISMO D was established to exceed 2000 mg/kg bw. Based on these results, according to Regulation (EC) 1272/2008, TISMO D does not have to be classified and has no obligatory labelling required for dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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