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Diss Factsheets
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EC number: 818-033-1 | CAS number: 1629579-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3'-oxybis(ethyleneoxy)bis(propylamine)
- EC Number:
- 224-207-2
- EC Name:
- 3,3'-oxybis(ethyleneoxy)bis(propylamine)
- Cas Number:
- 4246-51-9
- Molecular formula:
- C10H24N2O3
- IUPAC Name:
- 3,3'-[oxybis(ethane-2,1-diyloxy)]dipropan-1-amine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4,7,10-Trioxatridecan-1,13-diamin
- Physical state/appearance: yellowish liquid
- Purity: min 95%
- Impurities: 4,7-Dioxanonan-9-ol-1-amin
- Expiration date of the lot/batch: July 1985
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, FRG
- Weight at study initiation: mean males: 259 g; mean females: 218 g
- Housing: single housing (type DK-III, Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiaet (Klingentalmuehle AG, Kaiseraugst, CH) ad libitum
- Water: tap water ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: ca. 50 cm² of shaved dorsal/dorsolateral skin
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount applied: 2.15 mL/kg
- Concentration: undiluted - Duration of exposure:
- 24 hours
- Doses:
- 2150 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: check for mortality/moribund animals twice per day on working days and once per day on weekends/public holidays; clinical observation several times on the day application, afterwards at least once per day on working days; weighing on the day of application and on days 2, 6 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: assessment of local effects (30 - 60 min after removal of semiocclusive coverage and afterwards at least once per week)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 150 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male animal died 2 days after application of the test substance.
- Clinical signs:
- other: Clinical signs included dyspnoea, apathy, aggressiveness, staggering, poor general state.
- Gross pathology:
- Animal that died: lungs: severe edema
Sacrificed animals: no abnormalities in organs observed - Other findings:
- Local skin effects: 1 male animal moderate, 1 male animal superficial erosions with crust formation; other animals: profound necrosis.
Any other information on results incl. tables
Mortality:
Dose (mg/kg) |
2150 |
|
Males |
||
Dead animals/total animals after |
1 h |
0/5 |
1 d |
0/5 |
|
2 d |
1/5 |
|
7 d |
1/5 |
|
14 d |
1/5 |
|
Females |
||
Dead animals/total animals after |
1 h |
0/5 |
1 d |
0/5 |
|
2 d |
0/5 |
|
7 d |
0/5 |
|
14 d |
0/5 |
Mean body weights (g):
|
Dose (mg/kg) |
Weight day |
|||
0 |
2 |
6 |
13 |
||
Males |
2150 |
259 |
241 |
263 |
292 |
Females |
2150 |
218 |
241 |
211 |
231 |
Symptoms (cageside observations):
Dose (mg/kg) |
2150 |
Males |
|
Dyspnoea |
2D-5D |
Apathy |
2D-5D |
Agressiveness |
8D-9D |
Staggering |
2D-5D |
Poor general state |
2D-5D |
Females |
|
Dyspnoea |
2D-6D |
Apathy |
2D-5D |
Agressiveness |
6D-9D |
Staggering |
2D-6D |
Poor general state |
2D-6D |
D: Day
Local effects
Dose (mg/kg) |
2150 |
Males |
|
Profound necrosis |
1D-14D |
Edema |
1D-14D |
Females |
|
Profound necrosis |
1D-14D |
Edema |
1D-14D |
D: Day
Applicant's summary and conclusion
- Interpretation of results:
- other: slightly toxic
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the study, the LD50 for acute dermal toxicity in the rat has been determined to be 2150 mg/kg/bw.
- Executive summary:
Under the conditions of the study, the LD50 for acute dermal toxicity in the rat has been determined to be 2150 mg/kg/bw.
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