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EC number: 947-942-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The tests were performed based on OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD 111, Council Regulation (EC) No 440/2008, Guideline Part C – Methods for the Determination of Ecotoxicity, C.7. “Abiotic Degradation: Hydrolysis as a Function of pH”.
As the test item was expected to undergo fast hydrolysis in aqueous media the hydrolysis behaviour was investigated at 20 °C in demineralized water up to a degradation of >90 %. The stability was monitored by HPLC analysis with MS/MS-detection.
The concentration of the substance in the hydrolysis test solutions was determined by HPLC-MS/MS at defined time intervals after derivatization of the NCO function with dibutylamine.
Analytical result:
For the test item abiotic degradation >90 % was observed within 120 min at 20 °C in demineralized water.
Overall hydrolysis at 20 °C
2-ethylhexyl N-(6-isocyanatohexyl)carbamate first determination | 2-ethylhexyl N-(6-isocyanatohexyl)carbamate second determination | ||||||
Hydrolysis time | pH-value | Conc. | Recovery of the initial concentration | Hydrolysis time | pH-value | Conc. | Recovery of the initial concentration |
[µg/L] | [%] | [µg/L] | [%] | ||||
0 min | 6.4 | 67.44 | 100.0 | 0 min | 7.3 | 62.20 | 100.0 |
15 min | 6.6 | 43.34 | 64.3 | 15 min | 6.7 | 43.92 | 70.6 |
29 min | 6.8 | 27.20 | 40.3 | 30 min | 6.8 | 27.26 | 43.8 |
60 min | 7.3 | 13.05 | 19.3 | 60 min | 5.6 | 10.80 | 17.4 |
120 min | 7.4 | 2.81 | 4.2 | 120 min | 7.6 | 1.15 | 1.9 |
Half life time at 20 °C | t1/2= 0.44 hours | Half life time at 20 °C | t1/2= 0.34 hours | ||||
Hydrolysis rate constant | k = 4.36 x 10-4s-1 | Hydrolysis rate constant | k = 5.60 x 10-4s-1 |
Remark: pH-values could not be determined precisely with the pH meter due to lack of ions in the hydrolysis test solutions
The concentration of the test item after 120 min is determined to be <5 % of the initial value.
The test item is therefore considered to be hydrolytically unstable in demineralized water at 20 °C.
According to OECD 111 Guideline a sterility test was conducted at the end of >90 % hydrolysis. No microbes (colonies) were found. Therefore biotic degradation can be excluded.
The following half-life time and hydrolysis rate were calculated for 20 °C:
Half-life time: 0.4 hours (mean of two determinations)
Hydrolysis rate constant: k = 4.98 x 10-4s-1 (mean of two determinations)
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 0.4 h
- at the temperature of:
- 20 °C
Additional information
Due to the observed rapid degradation of the test item within minutes, an exact determination of half-life time or hydrolysis rate was not possible. Therefore the calculated halt-life times of the substance are estimated values related to the initial value at 0 min, which was set to 100 %.
Due to the poor water solubility of the test item, a test concentration of 100 μg/L (including 1 % acetonitrile as organic solvent additive) had to be applied for adequate dissolution. The low substance concentration in the hydrolysis test solutions did not allow the identification of hydrolysis products with the applied analytical method which has to be used to follow the degradation of the parent substance. Polymeric or oligomeric ureas as potential hydrolysis products of the substance could not be determined as they are assumed to be insoluble in water.
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