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Diss Factsheets
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EC number: 947-945-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Details on test solutions:
- Preparation of the test solutions/dispersions : The test substance was slightly soluble in water. Therefore, the test solution was prepared by dissolving 800mg/L of the test substance in 1.8 liters of potable water (passed through reverse osmosis system) with continuous stirring of 48 hrs. After the completion was 48 hrs stirring, the sample was run with HPLC to calculate the actual solubility of substance and the solubility calculated was 1.4 mg/L. the water solubility obtained from the stock prepared is then used for achieving test concentrations of 0.02 mg/L, 0.04 mg/L, 0.06 mg/L, 0.08 mg/L& 0.2 mg/L, respectively. pH: 7.2
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM- Common name: Zebra Fish (Danio rerio)- Source: Orange City Aquarium, Sitabuldi, Nagpur, MS (India) - Age at study initiation (mean and range, SD): 3-4 months- Length at study initiation (length definition, mean, range and SD): average 2.3 cm- Weight at study initiation: 0.268 g (average) - Housing :The fishes were kept in a static tank in tap water, under natural conditions along with proper feed and aeration.- Duration of housing : 15 days - Photoperiod : 12 hours light and 12 hours darkness- Oxygen content : 7.4 (mg/l)- pH : 7.1- Water temperature : 28 °C- Mortality (%): During last 14 days = 0% mortality- Diet : Standard brand feed, once daily
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 38.75 (mg of CaCO3)
- Test temperature:
- 21°C
- pH:
- 7.2
- Dissolved oxygen:
- 7.5 mg/l
- Salinity:
- Details not available
- Nominal and measured concentrations:
- 0.02 mg/L, 0.04mg/L, 0.06 mg/L, 0.08 m/L, & 0.2 mg/L.
- Details on test conditions:
- TEST SYSTEM- Test vessel: The test vessels used were all plastic aquaria having the water capacity of 5 liters.- Aeration: Aeration in test vessels was provided during the experiment after 24 hours of the start of the experiment.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.08 - < 0.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- A 96 h study was conducted for CAS No. 37330-39-5 on Zebra fish, at a test concentrations of 0.02 mg/L, 0.04mg/L, 0.06 mg/L, 0.08 m/L, & 0.2 mg/L. The fishes were moving slowly as compared to control. Mortality was found in the control aquaria. Mortality in each test concentration was nullified for the one mortality observed in control. LC0 (96 hours) (highest loading at which no mortality was observed) = Mortality was observed in all the five concentrationsLC50 (96 hours) Experimental = > 0.08 mg/L and <0.2 mg/LLC100 (96 hours) (lowest loading at which 100% mortality was observed) = 100% mortality was not in any of the concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for CAS No. 37330-39-5 on Zebra Fish was found to be > 0.08 mg/L and < 0.2 mg/L.
- Executive summary:
Fish Acute Toxicity test according to OECD Guideline 203 was conducted for Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene. The nominal concentration selected for the experiment were 0.02 mg/L, 0.04 mg/L, 0.06 mg/L, 0.08 mg/L& 0.2 mg/L and Zebra fishes were exposed to these concentration for 96 hours. The lethal concentrations LC50 was found to be > 0.08 mg/L and <0.2 mg/L.
Reference
Description of key information
Fish Acute Toxicity test according to OECD Guideline 203 was conducted forReaction mass of Cardanol diene and Cardanol monoene and Cardanol triene. The nominal concentration selected for the experiment were 0.02 mg/L, 0.04 mg/L, 0.06 mg/L, 0.08 mg/L& 0.2 mg/L and Zebra fishes were exposed to these concentration for 96 hours. The lethal concentrations LC50 was found to be > 0.08 mg/L and <0.2 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.085 mg/L
Additional information
Short term toxicty to fish
Summary of the weight of evidence results is presented below:
The experimental study indicates the LC50 to range between >0.08 to <0.2 mg/L. The results of the 2 QSAR results are presented in the table below
Sr no | Endpoint | Effect values | Basis for effects | Duration | Species | Sources |
1 | LC50 | 20.21 mg/L | Mortality | 96 hrs. | Oncorhynchus mykiss | Predicted data |
2 | LC50 | 10.30 mg/L | Mortality | 96 hrs. | Platichthys flesus | Predicted data |
However, the experimental study results shall be considered for the key value for the chemical safety assessment.
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