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EC number: 214-290-3 | CAS number: 1119-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Dodecyltrimethylammonium bromide
- EC Number:
- 214-290-3
- EC Name:
- Dodecyltrimethylammonium bromide
- Cas Number:
- 1119-94-4
- Molecular formula:
- C15H34N.Br
- IUPAC Name:
- dodecyltrimethylazanium bromide
- Details on test material:
- No further details were provided.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Initial body weight (males): 189 - 197 g
Initial body weight (females): 152 - 168 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Doses:
- 2000, 1000 or 200 mg/kg bw (dose volume of 10 mL/kg body weight)
- No. of animals per sex per dose:
- One animal per sex per dose: a total of six animals was used, one male and one female for each dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on day 1 (first day of dosing), day 8 and day 15.
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic post mortem examination
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Both animals dosed at 2000 mg/kg bodyweight died, the first animal 2 hours after dosing and the second animal 2 days after dosing. Both animals dosed at 1000 mg/kg body weight died after 2 days of dosing.
- Clinical signs:
- other: 2000 mg/kg bw: lethargy in 1 animal after 5 minutes of dosing, lethargy in 1 animal and piloerection in 1 animal adrer 2 hours of dosing, absence of reaction 1000 mg/kg bw: lethargy in 1 animal at 5 minutes after dosing, lethargy and piloerction in both
- Gross pathology:
- Macroscopic post mortem examination of the dead animals dosed at 2000 or 1000 mg/kg body weight revealed brownish fluid stomach content. Macroscopic post mortem examination of female animals dosed at 200 mg/kg body weight revealed irregular areas in the forestomach.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 for oral toxicity of Dodecyltrimethylammonium bromide in both female and male rats is >200 mg/kg bw and <1000 mg/kg bw.
- Executive summary:
In an oral toxicity study, Dodecyltrimethylammonium bromide was assessed for its potential to be acutely toxic to Wistar rats. One female and one male rat were exposed to a concentration of 200 mg/kg bw, 1000 mg/kg bw or 2000 mg/kg bw each (six animals in total). Clinical observations were performed in the first 5 minutes, 2 hours and 4 hours after dosing and daily from than onwards until day 15 (14 days after dosing). Bodyweights were measured on day 1 (day of dosing), on day 8 and on day 15. Animals dosed at 2000 mg/kg bodyweight both died; the first animal 2 hours after dosing and the second animal 2 days after dosing. Animals dosed at 1000 mg/kg body weight both died after 2 days of dosing. Macroscopic post mortem examination of the dead animals dosed at 2000 or 1000 mg/kg body weight revealed brownish fluid stomach content and examination of female animals dosed at 200 mg/kg body weight revealed irregular areas in the forestomach. Because no mortality occured at a dose level of 200 mg/kg bw and 100% mortality occured at a dose level of 1000 mg/kg bw, the LD50 of Dodecyltrimethylammonium bromide for both male and female rats is >200 mg/kg bw and <1000 mg/kg bw.
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