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Diss Factsheets
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EC number: 947-794-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 4.1 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 10.9
- Details on results:
- According to the results of the material balance (CURRENTA file no.: 2014/0048/03) the test item is described as a mixture of three constituents representing a content of > 99 %. Individual calibration curves were established for the three constituents using the test item as calibration substance with a stipulated content of 100 %.
The water solubility of the test item is calculated as sum of all signals (sum of Mannich Base (3 x / 4 x / 2 x substituted)). - Conclusions:
- The water solubility of the test item HPP 12879-1 in demineralized water at 20 °C (pH value 10.9) is determined to be 4.1 g/L.
- Executive summary:
The water solubility of the test item HPP 12879-1 in demineralized water was determined with the flask method at 20 °C based on OECD TG 105.
The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection.
According to the results of the material balance (CURRENTA file no.: 2014/0048/03) the test item is described as a mixture of three constituents representing a content of > 99 %. The constituents of the test item were split into separate HPLC peaks.
The water solubility of the test item is calculated as sum of all constituents.
Since it was assumed that the test item might not be stable in aqueous media over the required test duration of 72 hours according to OECD 105, additional measurements with a reduced stirring time of 24 hours were performed. Similar results were obtained. For the determination of the water solubility only the tests with 72 hours stirring time were taken into account.
The water solubility of the test item HPP 12879-1 in demineralized water at 20 °C (pH value 10.9) is determined to be 4.1 g/L.
Reference
Results of individual determinations and mean value
Water solubility test |
Flask A |
Flask B |
Flask C |
pH-value |
10.9 |
10.9 |
10.9 |
Concentration of the |
4.07 g/L |
4.14 g/L |
4.20 g/L |
Mean value |
4.1 g/L |
24 hours stirring time (additional determination)
Results of individual determinations and mean value
Water solubility test |
Flask D |
Flask E |
pH-value |
10.9 |
10.9 |
Concentration of the test item HPP 12879-1 |
3.77 g/L |
4.07 g/L |
Mean value |
3.9 g/L |
Since it was assumed that the test item might not be stable in aqueous media over the required test duration of 72 hours according to OECD 105, additional measurements with a reduced stirring time of 24 hours were performed.
Similar results were obtained. Therefore it can be stated that the water phase is saturated with the sample. For the determination of the water solubility only the tests with 72 hours stirring time were taken into account.
The relative standard deviation between the single determinations is < 15 %. The validity criteria of OECD 105 Guideline have therefore been met.
An example chromatogram of a water solubility test solution is attached in the field "illustration".
The water solubility of the test item HPP 12879-1 in demineralized water at 20 °C is determined to be: 4.1 g/L
Description of key information
The water solubility of HPP 12879-1 in demineralized water at 20 °C (pH value 10.9) is determined as 4.1 g/L with the flask method according to OECD 105.
Key value for chemical safety assessment
- Water solubility:
- 4.1 g/L
- at the temperature of:
- 20 °C
Additional information
The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection.
According to the results of the material balance (CURRENTA file no.: 2014/0048/03) the test item is described as a mixture of three constituents representing a content of > 99 %. The constituents of the test item were split into separate HPLC peaks.
The water solubility of the test item is calculated as sum of all constituents.
Since it was assumed that the test item might not be stable in aqueous media over the required test duration of 72 hours according to OECD 105, additional measurements with a reduced stirring time of 24 hours were performed. Similar results were obtained. For the determination of the water solubility only the tests with 72 hours stirring time were taken into account.
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