Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-888-8 | CAS number: 26657-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 - 29 Sep 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 91884-53-0
- IUPAC Name:
- 91884-53-0
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Composition sorbitansesquioctanat
- Physical state: liquid
- Analytical purity: 99%
- Lot/batch No.: ES 65631498
- Manufacturing date: 2005-06-28
- Shelf life: 36 months
- Stability in solution: stable to at least 150 °C, stable at pH 4 - 14
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
A stock solution of 1 g/L was prepared in dilution water. Each test concentration was prepared in a volumetric flask of 250 mL by dilution of appropiate amount of the stock solution.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: in-house culture since May 2001, originally obtained from Landesanstalt für Wasser und Abfallwirtschaft, Düsseldorf, Germany
- Method of breeding: 15 -20 adult organisms were held in one beaker filled with approx. 1400 mL dilution water. The temperature was 20 ± 2 °C and a light-dark circle of 16 to 8 h was kept. The water was renewed three times per week. Scenedesmus subspicatus served as food daily.
- Feeding during test: none
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20.0 - 20.7 °C
- pH:
- 7.59 - 8.48
- Dissolved oxygen:
- 61 - 79%
- Nominal and measured concentrations:
- Nominal: 0, 6.25, 12.5, 25, 50 and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel
- Type: open
- Material, size, headspace, fill volume: 50 mL glass beakers containing 30 mL test solution
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 6 (one for pysico-chemical measurements only, leaving 5 vessels for effects assessment)
- No. of vessels per control (replicates): 6 (one for pysico-chemical measurements only, leaving 5 vessels for effects assessment)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The dilution water was prepared separately in a PVC tank by mixing dechlorinated tap water with demineralized water and sulphuric acid. The dilution water was filtered through an active carbon filter.
- Total hardness: 2.376 mmol/L
- Carbonate hardness: 0.700 mmol/L
- pH: 8.02
- Alkalinity: 1.5 mmol/L (determined not in compliance with GLP)
- Ca/Mg ratio: 3.6:1
- Na/K ratio: 7.4:1
- Culture medium different from test medium: no
- Intervals of water quality measurement: pH, dissolved oxygen and temperature were measured daily in additional vessels
OTHER TEST CONDITIONS
- Photoperiod: 16 h light/ 8 h dark
- Light intensity: 700 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Immobilisation recorded after 1 and 2 days
TEST CONCENTRATIONS
- Preliminary study (limit test)
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: A mortality of 68% at 100 mg/L was observed. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 2 d
- Dose descriptor:
- EC0
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 2 d
- Dose descriptor:
- EC50
- Effect conc.:
- 39 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 35 - 44 mg/L
- Duration:
- 2 d
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - The test substance had a negative influence on the swimming behaviour of the test organisms.
- Effect values after 1 day: EC0 = 25 mg/L; EC50 = 65 mg/L; EC100 > 100 mg/L
- Mortality of control: none
- TOC measurements during the preliminary limit test indicated no loss of test substance during the course of the test - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50 (24h): 1.3 mg/L which is within the expected limit of 0.6 - 2.1 mg/L (experiment conducted 20 -21 Sep 2005) - Reported statistics and error estimates:
- The EC50 value was calculated with an US EPA computer programm (v 1.5) executing the Trimmed Spearman-Karber Method. The 95% confidence interval was indicated.
Any other information on results incl. tables
Table 1: Immobilisation of Daphnia
Test concentration [mg/L] | Number of immobile daphnia | Cumulative immobile daphnia [%] | ||
1 d | 2d | 1 d | 2 d | |
control | 0 | 0 | 0 | 0 |
6.25 | 0 | 0 | 0 | 0 |
12.5 | 0 | 0 | 0 | 0 |
25 | 0 | 0 | 0 | 0 |
50 | 7 | 21 | 28 | 84 |
100 | 21 | 24 | 84 | 96 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.