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EC number: 217-982-3 | CAS number: 2031-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-04-27 to 1994-04-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 500 mg/l nominal treatment
- Sampling method: Samples of test media were taken at the start and end of the test.
- Sample storage conditions before analysis: Refrigerated - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A 500 mg/l nominal concentration of the test substance was prepared by stirring overnight.
- Controls: Dilution water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Type and amount of food: Chlorella vulgaris at 500000 cells/ml
- Feeding frequency: Daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 204 mg/l as CaCO3
- Test temperature:
- 20.3 - 21.7ºC
- pH:
- 7.4 - 8.1
- Dissolved oxygen:
- 99 - 100% ASV
- Nominal and measured concentrations:
- Nominal: 0(Control), 500 mg/l
Measured concentration at start of test: 405 mg/l
Measured concentration at end of test: 436 mg/l
Mean measured concentration: 420 mg/l
Mean measured concentration as a percentage of nominal: 84.1%
The test results are presented and interpreted with reference to nominal concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Conical flasks
- Type: closed
- Material, fill volume: Glass, 150 ml of test medium
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted freshwater prepared by mixing (1:1) treated mains water and proprietary mineral water (Ashbourne, Still Natural Water (Nestle, UK. Limited).
- Culture medium different from test medium: no
- Chlorine: <0.1 mg/l (Total)
- Alkalinity: 134 mg/l as CaCO3
- Conductivity: 404 μS/cm
OTHER TEST CONDITIONS
- Adjustment of pH: no
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilization after 24 and 48 h - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0
- Reported statistics and error estimates:
- No toxic effects were observed in the test media, the test results were therefore not subject to statistical analysis.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EC50 value of > 500 mg/l and NOEC of ≥ 500 mg/l have been determined for the effects of the test substance on mobility of Daphnia magna based on nominal concentration of the substance. However it is likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Referenceopen allclose all
Description of key information
EC50 (48 h) > 500 mg/L (nominal, EU Method C.2); based on read across form CAS 2031-67-6
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 500 mg/L
Additional information
There are no reliable data available on the toxicity of diethoxy(methyl)silane (CAS 2031-62-1) to aquatic invertebrates. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read-across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read-across from the analogous substance triethoxy(methyl)silane (CAS 2031-67-6) has been applied to support the environmental hazard assessment of diethoxy(methyl)silane. Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
A 48 h EC50 value of > 500 mg/L and a NOEC of ≥ 500 mg/L have been determined for the effects of triethoxy(methyl)silane (CAS 2031-67-6) on the mobility of Daphnia magna based on nominal concentration of the substance. The study was conducted according to a standard guideline (EU Method C.2) and GLP (1994). Since the substance hydrolyses rapidly (< 2 min at pH 7 and 25 °C), it is very likely that the test organisms were primarily exposed to the hydrolysis product retained in the test media.
On the basis of the read across data, no short term hazard to aquatic invertebrates is expected from the substance diethoxy(methyl)silane (CAS 2031-62-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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