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Diss Factsheets
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EC number: 252-036-3 | CAS number: 34451-19-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Contact sensitization assays in guinea pigs: are they predictive of the potential for systemic allergic reactions?
- Author:
- Vial T. & Descotes J.
- Year:
- 1 994
- Bibliographic source:
- Toxicology 93: 63-75
- Reference Type:
- publication
- Title:
- Development and Validation of an Alternative Dermal Sensitization Test: The Mouse Ear Swelling Test (MEST)
- Author:
- Gad S. C. et al.
- Year:
- 1 986
- Bibliographic source:
- Toxicol. Appl. Pharmacol 84, 93-114
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- no pre-treatment with SDS before topical induction, time of evaluation after challenge not given
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study pre-dates validation of LLNA protocol.
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- IUPAC Name:
- propan-1-ol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- No data presented
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Concentration / amount:
- 100%
- Day(s)/duration:
- 7 days
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- 100%
- Day(s)/duration:
- 7 days
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- 100%
- Day(s)/duration:
- 7 days
- No. of animals per dose:
- Test group: 15
Control group: 6 - Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
Intradermal induction:
- No. of exposures: 2
- Test groups: test substance in vehicle, Freund's complete adjuvant (FCA), test substance in FCA
- Control group: Vehicle undiluted, FCA, vehicle in FCA (unclear which vehicle was used)
- Site: No data
- Frequency of applications: No data
- Concentrations: 100%
Topical induction (occlusive):
- Days after intradermal induction: 7
- No. of exposures: 1
- Test groups: Substance in vehicle applied to intradermal injection skin site
- Control group: Undiluted vehicle applied to intradermal injection skin site
- Duration: 48 hours
- Concentrations: 100%
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 21 days after induction
- Exposure period: 24 hours
- Test groups: Substance in vehicle applied to naive skin
- Control group: Undiluted vehicle applied to naive skin
- Concentrations: 100 %
- Evaluation (hr after challenge): No data
OTHER:
If necessary a rechallenge was planned 7 day after challenge. - Positive control substance(s):
- yes
- Remarks:
- Dinitrochlorobenzene (intradermal induction: 0.1 %; topical induction: 0.1 %; challenge: 0.1 %). Vehicle: propylene glycol
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100 %
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 100 %. No with. + reactions: 0.0. Total no. in groups: 15.0. Clinical observations: No data.
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 100 %
- No. with + reactions:
- 0
- Total no. in group:
- 6
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 100 %. No with. + reactions: 0.0. Total no. in groups: 6.0. Clinical observations: No data.
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 0.1 % in propylene glycol
- No. with + reactions:
- 15
- Total no. in group:
- 15
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: positive control. Dose level: 0.1 % in propylene glycol. No with. + reactions: 15.0. Total no. in groups: 15.0. Clinical observations: No data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guinea pig maximisation test, propanol was tested negative for skin sensitisation.
- Executive summary:
In a dermal sensitisation study (equivalent to OECD 406) with propanol, 15 guinea-pigs of the Hartley strain were tested using the method of Magnusson and Kligman. No dermal reactions were seen after challenging the test animals for 24 hours. In this study, propanol is not a dermal sensitiser.
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