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EC number: 203-927-0 | CAS number: 112-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27th November 1984 to 23rd January 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dodecyltrimethylammonium chloride
- EC Number:
- 203-927-0
- EC Name:
- Dodecyltrimethylammonium chloride
- Cas Number:
- 112-00-5
- Molecular formula:
- C15H34N.Cl
- IUPAC Name:
- N,N,N-trimethyldodecan-1-aminium chloride
- Reference substance name:
- Trimethyl(tetradecyl)ammonium chloride
- EC Number:
- 224-958-6
- EC Name:
- Trimethyl(tetradecyl)ammonium chloride
- Cas Number:
- 4574-04-3
- Molecular formula:
- C17H38N.Cl
- IUPAC Name:
- N,N,N-trimethyltetradecan-1-aminium chloride
- Reference substance name:
- Cetrimonium chloride
- EC Number:
- 203-928-6
- EC Name:
- Cetrimonium chloride
- Cas Number:
- 112-02-7
- Molecular formula:
- C19H42N.Cl
- IUPAC Name:
- N,N,N-trimethylhexadecan-1-aminium chloride
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- CAS number: 112-00-5
Mol. Weight: 263.9
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Remarks:
- Gaukler: D-6050 Offenbach/main. FRG
- Details on test animals or test system and environmental conditions:
- Animal species: Rabbit/white VIENNA
Animal Breeder: Gaukler; D-6050 Offenbach/main. FRG
Type of cage: cage made of stainless steel with wire mesh walk floors. floor area: 40 cm x 51 cm
N° of animals per cage: 1
Animal identification: Ear tattoo (=animal N°)
Room temperature/relative humidity: The animals were housed in fully air-conditioned rooms. Central air-conditioning guaranteed a range of 20 - 24 degrees Celsius for temperature and of 30 - 70% for relative humidity. There were no deviations from these ranges which influenced the results of the study.
Day/night rhythm: 12H/12H (6.00 - 18.00 hours/18.00 - 6.00 hours)
Bedding: No bedding in the cages: sawdust in the waste trays
Diet: KLIBA 341, 4MM. Firma Klingentalmuehle AG, Switzerland.
Drinking water: About 250mL tap water per animal per day
Acclimatization period: At least 8 days before the beginning of the study: same housing conditions as during the study
Clipping of the fur: At least 15 hours before the beginning of the study
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- Wetting of the test patch (2.5cm x 2.5cm) with the undiluted substance, and thus about 0.5mL of the test liquid is absorbed.
- Duration of treatment / exposure:
- Exposure périod: 4 hours
- Observation period:
- Observation period: 15 days
Readings: 30 - 60 minutes after removal of the test patches and 24 hours, 48 hours, 72 hours, 8 days, 15 days after the beginning of application. - Number of animals:
- 3 (males)
- Details on study design:
- Exposure period: 4H
Number of animals: 3 males / 0 female
Mean weight: 3.10 kg
Application area: 2.5 cm x 2.5 cm
Form of application: unchanged
Application volume: Wetting of the test patch (2.5cm x 2.5cm) with the undiluted substance, and thus about 0.5mL of the test liquid is absorbed.
Application site: Upper third of the back or flanks
Removal of the tes substance: At the end of the exposure period with lutrol and lutrol/water (1:1)
Observation period: 15 D
Readings: 30 - 60 minutes after removal of the test patches and 24 hours, 48 hours, 72 hours, 8 days, 15 days after the beginning of application.
Negative control: untreated skin sites of the same animal.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 8 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 8 d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 8 d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 15 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 15 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 15 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 8 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 8 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 8 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 15 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 15 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 15 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- ME animal#1 erythema: 3.3 edema: 2.7
MEanimal#2 erythema: 2.3 edema: 0.3
ME animal#3 erythema: 3.3 edema: 2.7
ME erythema: 3.0 edema: 1.9
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Very irritating / causes haemorrhage 24 hours after application of the patch (30 to 60 minutes of application).
Skin irritating Category 2 (GHS classification). - Executive summary:
Title: Report on the acute dermal irritation/corrosivity to the intact dorsal skin of the white rabbit based on OECD (404).
Testing facility: BASF aktiengesellschaft
Aim of the study: Assessment of a possible irritating or corrosive potential to the skin.
Test substance: CAS N°112 -00 -5 / 84/401
Conclusion: Very irritating / causes haemorrhage 24 hours after application of the patch (30 to 60 minutes of application). Skin irritating Category 2 (GHS classification).
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