cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-ylmethyl methanesulphonate monohydrochloride

Auto flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment. No information on purity of the substance.

Qualifier:

according to guideline

Guideline:

EU Method A.16 (Relative Self-Ignition Temperature for Solids)

Deviations:

yes

Remarks:

A heating rate of 1.0-1.2 deg C/min or 0.6 deg C/min is used instead of 0.5 deg C/min due to an alternative Swiss Chemical Industry method and technical restriction of the apparatus used. Cylindric wire baskets with 0.2 mm openings are used.

Qualifier:

according to guideline

Guideline:

other: VDI Guideline 2263 Part 1: Autoignition-Testing as per Grewer

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

other: ESCIS Expert Commission for Safety in the Swiss Chemical Industry, Booklet 1 ''Sicherheitstests fur Chemikalien''.

Deviations:

not specified

Principles of method if other than guideline:

Modifications to the EU A.16 Method: A heating rate of 1.0-1.2 deg C/min or 0.6 deg C/min is used instead of 0.5 deg C/min due to an alternative Swiss Chemical Industry method and technical restriction of the apparatus used. Cylindric wire baskets with 0.2 mm openings are used.

GLP compliance:

not specified

Remarks on result:

no self ignition observed under the test conditions

-heating rate: 1.0 deg C/min

-the sample is heated from room temperature (about 20 deg C) to +/- 220 deg C (above the melting point)

-melting endotherm is observed at about 145 deg C

-the sample shows no self-heating up to 400 deg C in the test run

Conclusions:

In conclusion, the tested substance T001202 is not auto-flammable up to the temperature applied in the test run. The substance has no relative self-ignition temperature.

Reference 2

Endpoint:

auto-ignition temperature, other

Remarks:

minimum ignition temperature of a dust cloud

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment. No information on purity of the substance.

Qualifier:

according to guideline

Guideline:

other: VDI Guideline 2263 Part 1: Ignition Temperature BAM-oven

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

other: ESCIS Expert Commission for Safety in the Swiss Chemical Industry, Booklet 1 ''Sicherheitstests fur Chemikalien''.

Deviations:

not specified

GLP compliance:

not specified

Remarks on result:

other: The Minium Ignition Temperature determined in the BAM oven is 450 deg C.

The Minium Ignition Temperature determined in the BAM oven is 450 deg C.

Conclusions:

The Minimum Ignition Temperature determined in the BAM oven for T001202 is 450 deg C.

Description of key information

Two different studies (Klimisch 4, Product Safety Center of Janssen Pharmaceutica N.V.) are available on autoflammability and are used in a weight of evidence (WoE) approach. The first study was a BAM oven test in which the minimum ignition temperature was determined to be 450°C. The second study is a Grewer oven test with an end temperature of 400°C, in which no self-ignition of the test item was observed, i.e. the substance does not have a relative self-ignition temperature. Clearly, the substance does not need to be considered as autoflammable.