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EC number: 812-963-1 | CAS number: 178436-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-04-21 to 2017-10-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- adopted 27 July 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
- Remarks:
- Additionally: visual methods
Test material
- Reference substance name:
- Ceramide IIIB
- IUPAC Name:
- Ceramide IIIB
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 100.1 °C
- Atm. press.:
- 1 010 hPa
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: Mp: ±0.4 °C; by DSC and visual methods
Any other information on results incl. tables
Capillary method
The melting point / range was determined using a using a melting point system (MP80, Mettler Toledo) according DIN EN ISO 3143 (previous version: DIN 53736). Two runs were done. The onset-temperature is 101 °C. The clear point was reached at 104 °C.
The thermic behaviour ofCeramide III bwas tested with a boiling point capillary from room temperature up to 300 °C with a heating rate of 10 °C/min.
Bubbles rose from approx. 250°C to 275 °C. Finally, after cooling, the content of the tube is colored and brownish residues are obvious at the wall of the tube.
DSC / TGA
As preliminary tests first TGA and DSC runs were performed.
As the substance was obviously modified within the first heating period to 250 °C, the DSC main test was focused on the melting behavior
According to the visual inspection,Ceramide III bstarts liquefying at 101 °C.
For the determination of the melting point, the main DSC test was performed in triplicate.
The melting points were read from the second and the third heating run of each test as the peak
top temperature of the allocated melting peak.
After the test procedure, the samples were re-weighed in order to check for a significant sample loss indicating potential interfering non-melting processes. For none of the samples a significant weight loss was recorded (< 0.5 %).
Test[ |
Peak temperature [°C] |
Enthalpy (normalised) [J/g] |
|
|
|
100.6 |
79.1 |
|
Test 1 |
99.8 |
72.6 |
|
|
m100.2 |
m75.9 |
|
|
100.5 |
81.0 |
|
Test 2 |
99.7 |
74.0 |
|
|
m100.1 |
m77.5 |
|
|
100.5 |
81 |
|
Test 3 |
99.7 |
74 |
|
|
m100.1 |
m77.5 |
|
Average |
100.1 |
77.0 |
|
SD |
0.4 |
3.8 |
|
CV [%] |
0.44% |
4.99% |
In the TGA test, a sample of the test item was heated from 30 °C to 675 °C in an inert gas atmosphere (N2). A first drop was detected beginning at 225.0 °C (onset) attended by a weight loss of about 10 %. The main drop was detected beginning at 325.4 °C (onset). Up to 400.2 °C a total weight loss of 99.9 % was recorded.
By means of DSC forCeramide III ban average melting point of 100.1 ± 0.4 °C was measured which is in accordance with the one measured by visual observation in the melt microscope (start liquefaction at 101 °C).
Applicant's summary and conclusion
- Conclusions:
- Melting point is 100.1 °C ± 0.4 °C at 1010 hPa, without decomposition and sublimation.
- Executive summary:
The melting temperature of Ceramide IIIB was determined according to Guideline OECD 102 with differential scanning calorimetry and visual methods. The melting point is 100.1 °C ± 0.4 °C at 1010 hPa, without decomposition and sublimation.
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