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EC number: 225-896-2 | CAS number: 5137-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitization:
A prophetic patch test on humans of wool fabric impregnated with the 0.5%(w/w) of the test chemical, produced no evidence of irritation or sensitization.
Hence, Methyl(trioctyl)azanium chloride can be considered to be not sensitizing to human skin.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitization:
In different studies,Methyl(trioctyl)azanium chloridehas been investigated for potential for dermal sensitization to a greater or lesser extent. The studies are based on in vivo experiments in guinea pigs, humans for the target chemical as well its structurally similar chemicals.
Prophetic patch tests were conducted to determine the allergenic potential of the test chemical. Methyl(trioctyl)azanium chloride impregnated in wool fabric(1 inch square) a 0.5% (w/w) concentration and untreated wool fabric (1 inch square) was applied to the intact skin of left arm of 31 human volunteers for 48 hours.
After 2 weeks of rest period, the humans were sensitized with the same dose to approximately same area of the skin for 48 hours.
A prophetic patch test on humans of wool fabric impregnated with the 0.5%(w/w) of the test chemical, produced no evidence of irritation or sensitization. Hence, Methyl(trioctyl)azanium chloride can be considered to be not sensitizing to human skin.
This is supported by the results of the dermal sensitization study carried out in guinea pigs to determine the allergic potential of Methyl(trioctyl)azanium chloride. A total of 30 male guinea pigs were used for the study.10 test guinea pigs, 10 positive control guinea pigs; 10 control guinea pigs - 5 receiving challenge dose of test compound without prior sensitizing dose, 5 receiving challenge dose of positive control [DNCB] without prior sensitizing dose. DNCB was used as the positive control substance.
Guinea pigs were given intradermal injections of 0.1 ml of 0.1% suspensions of test compound or positive control in a mixture containing 1 volume of propylene glycol and 19 volumes of saline.
The challenge dose of DNCB in the positive control guinea pigs caused a greater skin response 24 and 48 hours after injection than the initial sensitizing dose. However, the response to the DNCB challenge dose was three times more intense than the response to the test chemical challenge dose. The response of the 5 control guinea pigs receiving the challenge dose without prior sensitization was of the same intensity as that obtained from the initial intradermal dose in the positive control group.
The initial intradermal sensitizing dose of the test chemical caused inflammatory responses in guinea pigs 24 and 48 hours after the intradermal injection. The challenge dose (last intradermal injection) of the test chemical caused greater skin response in than the initial sensitizing dose in test guinea pigs at 24 and 48 hours after injection.
The response of 5 control guinea pigs receiving the challenge dose of the test chemical without prior sensitizing doses was greater than the response from the initial intradermal dose of the test chemical but was of the same intensity as that of the control guinea pigs receiving the test chemical.
The observations for sensitization potential of Methyl(trioctyl)azanium chloride gave equivocal results.
The above results are supported by Buehler test conducted to determine the allergic potential of the structurally similar chemical. The study was performed according to OECD 406 Guidelines. Irritation to the skin was seen following challenge with 1% test material but no indication of any sensitization. Hence, the test chemical was considered to be not sensitizing to guinea pig's skin.
These results are further supported by a Human repeated insult patch test (HRIPT) carried out to evaluate the dermal sensitization potential of the structurally similar chemical. 2% solution of the test chemical was freshly prepared daily. The test chemical when tested on human volunteers by Human repeated insult patch test (HRIPT) using 2% concentration produced no skin allergic reactions. Hence, it was considered to be not sensitizing to skin.
Even though the results of the guinea pig study for the target chemical gave an equivocal result but results of patch test in humans using the target chemical along with the available data for thestructurally similar read across chemicalslend support to the claim that Methyl(trioctyl)azanium chloride can indeed be not sensitizing to skin. Hence, Methyl(trioctyl)azanium chloride can be considered to be not sensitizing to skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Available data for Methyl(trioctyl)azanium chloride indicates that it is likely to not likely to cause any dermal sensitization. Hence, Methyl(trioctyl)azanium chloride can be considered to be not sensitizer to skin.
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