Registration Dossier
Registration Dossier
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EC number: 911-418-6 | CAS number: 55965-84-9
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- method to determine freezing temperature
- Specific details on test material used for the study:
- Kathon" 886F Biocide is an aqueous formulation consisting of 5-chloro-2-methyl-4- isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in a 3 to 1 weight ratio and a stabilizer. The nominal level of the active ingredients in this formulation is approximately 14%. Kathon" 886F, Lot 6110C015, was used as both the Purified
Active Substance of Stated Specification and the Technical Material. Lot 61 10C015 is a clear, pale yellow liquid at room temperature and was found to contain 10.81% RH-651 and 3.24% RH-573, total Al = 14.05%, when analyzed via GLP guidelines - Key result
- Melting / freezing pt.:
- < -25 °C
- Atm. press.:
- 1 atm
- Conclusions:
- The freezing temperature of KathonB 886F Biocide is less than - 25°C
- Executive summary:
The freezing temperature was determined by cooling the test substance at a controlled rate, in accordance with British Standard 4633: 1970, until a sample temperature plateau was observed at the crystallising point.
A small glass tube containing test substance (1 0 ml) at room temperature was placed in a larger tube, in a water bath, where the temperature of the cooling medium was about -30°C. The sample was stirred continuously and the temperature monitored with a thermocouple. A second test was performed using a fresh sample.
The freezing point of KathonB 886F Biocide was determined to be less than -25°C at which temperature the testing was halted.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-06 till 1999-04-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- capillary method
- Melting / freezing pt.:
- >= 46.2 - <= 50.3 °C
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting point of CIT is between 46.2-50.3°C.
- Executive summary:
The melting point of the test substance 5 -chloro-2 -methyl-2H-isothiazol-3 -one (CIT) was detemined according to OECD guideline 102. Crystalline test substance was obtained from the supplied 8% solution in ethyl acetate by evaporation of the solvent. The test substance was heated in a one side closed glass capillary within a metal block and was observed for transition of the physical state. The transition temperature was noted.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-06 till 1999-04-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-confrom study withour deviations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- capillary method
- Melting / freezing pt.:
- >= 39 - <= 42.8 °C
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting point of MIT is between 39.0-42.8°C.
- Executive summary:
The melting point of the test substance 2 -methyl-2H-isothiazol-3 -one (MIT) was detemined according to OECD guideline 102. The test substance was heated in a one side closed glass capillary within a metal block and was observed for transition of the physical state. The transition temperature was noted.
Referenceopen allclose all
NA
Description of key information
C(M)IT/MIT (3:1):
melting onset at 22.2C, with a peak at 35.1C (DOW)
-25C concentration 14.05% (Dow)
-23C concentration approx 14% (Thor)
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 22.2 °C
Additional information
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