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Diss Factsheets
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EC number: 208-066-4 | CAS number: 507-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 2017-08-25 to 2017-11-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- <= -20 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting point/range of the test item was determined to be not above -20 °C.
- Executive summary:
A study was performed according to OECD TG 102 and Commission Regulation (EC) No. 440/2008 method A.1 in order to determine the melting point/range of the test item by using differential scanning calometry method (DSC). One DSC measurement in an open crucible and two additional DSC measurements in closed crucibles were performed. The test item was cooled down to -80 °C with 10 K/min (kept for 30 min) and afterwards heated up to 10 °C, 20 °C and 25 °C with 10 K/min. During cooling down an exothermal effect was visible between -30 and -50 °C and during heating an endothermal effect was visible between -20 and 0 °C. During the measurements the test item remained unchanged. In addition to the DSC measurement the test item was cooled down to -26 °C with a freezer. After 12 hours at this temperature the test item was solidified. Under consideration of both the DSC measurements and the visual check at about -26 °C it was concluded that the melting point of the test item is below -20 °C. (reference 4.2-1).
Reference
Individual results - melting point/range (DSC measurement)
One DSC measurement in an open crucible and two additional DSC measurements in closed glass crucibles were performed. In each case the test item was cooled down to -80 °C with a cooling rate of 10 K/min, -80 °C were kept for 30 min and afterwards the test item was heated up to 10 °C, 20 °C, and 25 °C, respectively, with a heating rate of 10 K/min. During the cooling down the DSC measurements showed an exothermal effect in the temperature range of -30 to -50 °C. During heating up the measurements showed two broad endothermal effects in the temperature range of -55 to -20 °C and in the temperature range of -20 to 0 °C, respectively. The onset temperature (see Table 1) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.
The results of the DSC measurements are summarized in Table 1.
Table 1: Melting point (DSC measurement)
Ident No. |
Test item (mg) |
Temperature range (endothermal) (°C) |
Onset (°C) | Crucible | Observations after the measurement |
36538 | 33.03 | (-50) - (-20) (-20) - (0) |
-46.68 -15.01 |
open glass | Test item was unchanged; mass loss: 61 % |
36541 | 14.04 | (-55) - (-30) (-30 - (-10) |
-50.22 -22.89 |
closed glass | Test item was unchanged |
36702 | 18.56 | (-55) - (-30) (-30) - (-5) |
-50.78 -22.36 |
closed glass | Test item was unchanged |
Additionally to the DSC measurements, the liquid test item was brought to a temperature of approx. -26 °C with the help of a freezer. A visual check after around 12 h showed a solidified test item which however melted nearly spontaneously completely at room temperature. Taking both the DSC measurements and the visual check at approx. -26 °C into account it can be concluded that the melting point of the test item is below -20 °C.
In
literature a polymorphism of the test item compounds is reported with
different phases at low temperatures. The results of two endothermal
effects in the DSC measurements agree with such phase transitions
reported in literature. The latter describes the formation of an
orientationally disordered plastic crystalline phase by colling down the
test item below its freezing point of approximately -25 to -23 °C.
Description of key information
The melting point of the substance is below -20 °C.
Key value for chemical safety assessment
Additional information
In accordance with column 2 Annex VII section 7.2 of Regulation (EC) No 1907/2006 (REACH), the test on melting point does not need to be conducted as the melting point of the substance is below -20°C.
A study was performed according to OECD TG 102 and Commission Regulation (EC) No. 440/2008 method A.1 in order to determine the melting point/range of the test item by using differential scanning calometry method (DSC). One DSC measurement in an open crucible and two additional DSC measurements in closed crucibles were performed. The test item was cooled down to -80 °C with 10 K/min (kept for 30 min) and afterwards heated up to 10 °C, 20 °C and 25 °C with 10 K/min. During cooling down an exothermal effect was visible between -30 and -50 °C and during heating an endothermal effect was visible between -20 and 0 °C. During the measurements the test item remained unchanged. In addition to the DSC measurement the test item was cooled down to -26 °C with a freezer. After 12 hours at this temperature the test item was solidified. Under consideration of both the DSC measurements and the visual check at about -26 °C it was concluded that the melting point of the test item is below -20 °C. (reference 4.2 -2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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