Registration Dossier
Registration Dossier
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EC number: 203-694-5 | CAS number: 109-67-1
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
QSAR model, iSafeRat holistic approach v1.7, key study, validity 1:
96h-LC50 = 5.9 mg/L (95% CL: 5.4 - 6.5 mg/L).
Short-term toxicity to aquatic invertebrates
OECD 202, GLP, key study, validity 2
48h-EC50 (Daphania magna)= 35 mg/L
Toxicity to aquatic algae:
OECD 201, GLP, key study, validity 2:
72h-EC50 (growth rate) = 79 mg/L
72h-NOEC (growth rate) <= 15 mg/L
Toxicity to microorganisms:
QSAR model, iSafeRat holistic approach v1.7, key study, validity 1:
30 -180min EC50 = 45 mg/L (95% CL: 30 - 67 mg/L).
Additional information
Two valid acute experimental studies based on international guidelines (and GLP) and two QSAR predictions are available to assess the aquatic toxicity of the registered substance.
Among all data available, a toxic effect was observed for all aquatic organisms: the 48h-EC50 for Daphnia magna, the 72h-EC50 for algae and the 30 -180min EC50 for microorganisms were 35 mg/L, 79 mg/Land 45 mg/L, respectively. The highest toxicity was observed for fishes with a LC50 (96hrs) of 5.9 mg/L predicted with QSAR.
According to the available data, the lowest LC50 for fishes is in the range 1 - 10 mg/L.
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