Registration Dossier
Registration Dossier
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EC number: 204-526-3 | CAS number: 122-18-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity in rodents
- Author:
- U.S. National Library of Medicine
- Year:
- 2 010
- Bibliographic source:
- HSDB
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical was performed in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzalkonium chloride
- EC Number:
- 616-786-9
- Cas Number:
- 8001-54-5
- Molecular formula:
- unspecified
- IUPAC Name:
- Benzalkonium chloride
- Details on test material:
- - IUPAC Name: Benzalkonium chloride
- Smiles: c1(C[N+](C)(C)*)ccccc1.[ClH-]
- Molecular weight :170.662 g/mol
- Substance type:organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1100 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 1100 mg/kg bw
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral toxicity dose (LD50) value was considered to be 1100 mg/kg bw, when male rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity study was performed using test chemical in male rats at the dose concentration of 1100 mg/kg bw. 50% mortality was observed at dose 1100 mg/kg bw. Hence, LD50 value was considered to be 1100 mg/kg bw, when male rats were treated with test chemical orally.
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