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EC number: 225-004-1 | CAS number: 4602-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 December 1982 - 23 December 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Non-guideline, non-GLP study, however experimental details and results are well-reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity was tested in male and female WISW-strain rats. Applications were made on scarified and intact skin and test animals were observed for 14-days for any signs of reaction and mortality.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Farnesol
- EC Number:
- 225-004-1
- EC Name:
- Farnesol
- Cas Number:
- 4602-84-0
- Molecular formula:
- C15H26O
- IUPAC Name:
- farnesol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: BOR: WISW (substrain SPF TNO)
- Weight at study initiation: 190.0 to 258.0 g for males, 160.0 to 205.0 g for females
- Housing: maximum 5 rats per cage
- Diet (e.g. ad libitum): Pellets with added vitamins
- Water (e.g. ad libitum): Aqua fontana fit for human consumption, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2 °C
- Humidity (%): 45 to 55%
- Photoperiod (hrs dark / hrs light): 12 hour photoperiod with fluorescent lighting (120 Lux)
IN-LIFE DATES: From: 7/12/1982 To: 23/12/1982
Administration / exposure
- Type of coverage:
- other: Scarified and intact skin
- Vehicle:
- other: white Vaseline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Clipped area (8 x 5 cm) on the back of each test animal; one group was abraded with a clean clipper blade to penetrate the horny layer of the epidermis without causing bleeding, while the other group was left intact.
- Type of wrap if used: Dose secured for 24 hours with gauze pads and plastic material
REMOVAL OF TEST SUBSTANCE
- Washing: Substance removed with wet disposable gauze
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied: 2.40 to 3.88 g
- Concentration: 10%
- Constant volume or concentration used: Constant concentration, the application sample was weighed per animal
- For solids, paste formed: yes - Duration of exposure:
- 24h
- Doses:
- 10%
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical-toxicological signs (modified Irvin-Screening) recorded at 2, 4, 24, 48 and 72 hrs and 7 and 14 days after application; body weight recorded at the start and end of experiment on the surviving animals.
- Necropsy of survivors performed: yes, immediately after all mortalities and upon study completion for the survivors
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Skin alterations (modified Draize-Scheme) recorded at 24 hours and 3, 7 and 14 days after application
Results and discussion
- Preliminary study:
- Pairs of female rats were scarified and administered with 5 and 15 g/kg bodyweight.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- No mortalities were observed
- Clinical signs:
- other: The sample did not induce any clinical-toxicological symptoms and no skin alternations were observed.
- Gross pathology:
- No gross pathological findings were recorded.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of 10% farnesol in Vaseline was determined to be > 15 g/kg bodyweight for rat.
- Executive summary:
The acute dermal toxicity of 10% farnesol in Vaseline was tested in male and female WISW rats. A single dose of 15 g/kg bodyweight was applied on scarified and intact skin of the test animals and secured for 24 hours. Mortality, clinical signs of toxicity, changes in bodyweight, skin alterations and gross pathology were observed for 14 days following application. No mortalities were observed and the dermal LD50 was determined to be > 15 g/kg bodyweight. This study is reliable with restrictions (Klimisch 2) as it was well-designed and well-reported, however was not performed according to any specific guideline or to GLP.
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