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EC number: 205-293-0 | CAS number: 137-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
- Qualifier:
- according to guideline
- Guideline:
- other: Zahn-Wellens method
- Principles of method if other than guideline:
- Biodegradation study was conducted for 20 days for evaluating the percentage biodegradability of test substance Metam-sodium. The study was performed according to Zahn-Wellens method.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : Metam-sodium
- Common name: Sodium methyldithiocarbamate
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- 20 d
- Initial conc.:
- 200 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Remarks:
- or COD
- Parameter:
- % degradation (DOC removal)
- Remarks:
- or COD
- Value:
- 1
- Sampling time:
- 1 d
- Remarks on result:
- other: Other details not known
- Parameter:
- % degradation (DOC removal)
- Remarks:
- or COD
- Value:
- 8
- Sampling time:
- 6 d
- Remarks on result:
- other: Other details not known
- Parameter:
- % degradation (DOC removal)
- Remarks:
- or COD
- Value:
- 84
- Sampling time:
- 19 d
- Remarks on result:
- other: Other details not known
- Parameter:
- % degradation (DOC removal)
- Remarks:
- or COD
- Value:
- 77
- Sampling time:
- 20 d
- Remarks on result:
- other: Other details not known
- Details on results:
- Test substance undergoes 1, 8, 84 and 77% degradation by DOC removal or COD parameter in 20 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The percentage degradation of test substance Metam-sodium was determined to be 1, 8, 84 and 77% by DOC removal or COD parameter in 20 days. Thus, based on percentage degradation, Metam-sodium is considered to be readily biodegradable in water.
- Executive summary:
Biodegradation study was conducted for 20 days for evaluating the percentage biodegradability of test substance Metam-sodium (CAS no. 132-87-6). The study was performed according to Zahn-Wellens method under aerobic conditions. Activated sludge (not adapted) was used as a test inoculum for the study. Initial test substance conc. used in the study was 200 mg/l based on TOC removal, respectively.The initial TOC concentration after 3 hours was -21%.The percentage degradation of test substance Metam-sodium was determined to be 1, 8, 84 and 77% by DOC removal or COD parameter parameter in 20 days. Thus, based on percentage degradation, Metam-sodium is considered to be readily biodegradable in water.
Reference
Description of key information
Biodegradation study was conducted for 20 days for evaluating the percentage biodegradability of test substance Metam-sodium (CAS no. 132-87-6) (IUCLID dataset, 2000). The study was performed according toZahn-Wellens method under aerobic conditions. Activated sludge (not adapted) was used as a test inoculum for the study. Initial test substance conc. used in the study was 200 mg/l based on TOC removal, respectively.The initial TOC concentration after 3 hours was -21%.The percentage degradation of test substance Metam-sodium was determined to be 1, 8, 84 and 77% by DOC removal or COD parameter parameter in 20 days. Thus, based on percentage degradation, Metam-sodiumis considered to be readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Experimental study for the target compound Metam-sodium (CAS No. 137-42-8) and various supporting studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from secondary source (IUCLID dataset, 2000), biodegradation experiment was conducted for 20 days for evaluating the percentage biodegradability of test substance Metam-sodium (CAS no. 132-87-6). The study was performed according to Zahn-Wellens method under aerobic conditions. Activated sludge (not adapted) was used as a test inoculum for the study. Initial test substance conc. used in the study was 200 mg/l based on TOC removal, respectively.The initial TOC concentration after 3 hours was -21%.The percentage degradation of test substance Metam-sodium was determined to be 1, 8, 84 and 77% by DOC removal or COD parameter parameter in 20 days. Thus, based on percentage degradation, Metam-sodium is considered to be readily biodegradable in water.
In a supporting study from authoritative database (HSDB and PubChem, 2017) for the read across chemical 1,2-Ethanediylbiscarbamodithioic acid disodium salt (CAS no. 142-59-6), biodegradation experiment was conducted for evaluating the percentage biodegradability of read across substance 1,2-Ethanediylbiscarbamodithioic acid disodium salt (CAS no. 142-59-6). The study was performedunder aerobic conditions using activated sludge as a test inoculum. Test chemical conc. used for the study were 9.8, 10.2, 9.6 and 9.8 mg/l, respectively. Test chemical was fed over four consecutive days to a bench scale activated sludge unit at a conc. of 3 liters synthetic sewage per day. The percentage degradation of test substance1,2-Ethanediylbiscarbamodithioic acid disodium salt was determined to be 96% after a 1 day period. Thus, based on percentage degradation, 1,2-Ethanediylbiscarbamodithioic acid disodium salt is considered to be readily biodegradable in nature.
For the read across chemical ammonium N-methyldithiocarbamate (CAS no. 39680-90-5), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance ammonium N-methyldithiocarbamate (CAS no. 39680-90-5). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance ammonium N-methyldithiocarbamate was determined to be 2-13, 41 and 73-87% by BOD, O2 consumption, TOC removal, Test material analysis and HPLC parameter in 28 days. Thus, based on percentage degradation (73-87%), ammonium N-methyldithiocarbamate is considered to be readily biodegradable in nature.
On the basis of above results for target chemical Metam-sodium (from secondary source IUCLID dataset, 2000) and for its read across substance (from authoritative database HSDB and PubChem, 2017), it can be concluded that the test substance Metam-sodium can be expected to be readily biodegradable in nature.
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