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Diss Factsheets
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EC number: 695-101-5 | CAS number: 1275611-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No test data available. Profiling and QSARs indicate a low risk for sensitisation, and due to use in industrial and professional setting only, with the application of adequate PPE related to the severe corrosive properties of the etheramine, exposures are limited. There are no reports on incidents of sensitisation to diamine methylated available.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are no reports on incidences of sensitisation from industrial production and use of the substance.
The molecular structure of the diamines does not contain toxicophores indicating a concern for sensitization. Profiling in QSAR Toolbox (v.4.3) indicate that Diamine methylated is not expected to bind to protein,:
General mechanistic
- Protein binding by OASIS: No alert found
- Protein binding by OECD: No alert found
- Protein binding potency: Not possible to classify according to these rules (GSH)
- Protein binding potency Cys (DPRA 13%): Grey zone 9-21%
- Protein binding potency Lys (DPRA 13%): Less than 9%
-
Endpoint specific
- Keratinocyte gene expression: Not possible to classify according to these rules
- Protein binding alerts for skin sensitization according to GHS: No alert found
- Protein binding alerts for skin sensitization by OASIS: No alert found
- Protein Binding Potency h-CLAT: No alert found
- Respiratory sensitisation: No alert found
No metabolism/transformations are predicted for:
- Autoxidation simulator
- Autoxidation simulator (alkaline medium)
- Dissociation simulator
- Hydrolysis simulator (acidic, basic, neutral)
Metabolism is predicted by the Skin metabolism simulator. The skin simulator was developed as a simplified mammalian liver metabolism simulator (assuming that metabolism in liver microsomes is similar to that of skin compartment). This predicts successive demethylation of the methyl-groups from the terminal Nitrogen with subsequent oxidation to formaldehyde and formic acid. However, extensive metabolism is not expected.
The Toolbox automated process for prediction of skin sensitisation predicted negative. (By read-across to 1,14-Tetradecanediol, which is not considered structurally relevant)
Other QSARs for sensitisation:
- DEREK: Skin sensitisation in mammal is NON-SENSITISER- No misclassified or unclassified features
- TOPKAT: Non-Sensitizer (low validity)
- VEGA (CAESAR v2.1.6): Sensitizer (good reliability), although substances from training set includes: sulfates, nitrogen-oxygen-ring structures and acid chloride, but no tert. amines!
- Danish QSAR DB battery model (1.0) – Out of domain (Leadscaope 1.0: Pos; SciQSAR 1.0: Neg.)
Discussion: dermal
There is no data on sensitisation available forDiamine methylated. Available studies indicate that the substance is highly corrosive. There are no consumer exposures, only industrial/professional use under circumstances involving the use of PPM following the classification as corrosive cat. 1B. Consequently, due to limited exposures, animal testing is not required.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Diamine methylatedhas a low vp pressure (2.3E-04 Pa at 20°C, experimental) and its use is limited to industrial settings that do not involve the forming of aerosols, particles or droplets of an inhalable size. So exposure to humans via the inhalation route will be unlikely to occur.
Additionally, information from profiling for expected protein interaction and QSARs for sensitisation result to a low concern.
Justification for classification or non-classification
There is no information available from testing. Available data is not robust enough to derive a definite conclusion. However the lack of structural alerts in DEREK, without misclassified or unclassified features, indicates a low likelihood for sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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