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EC number: 238-942-1 | CAS number: 14871-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation
Based on the result obtained from the studies available for the structurally similar read across chemicals, it can be concluded that the test chemical cannot cause skin sensitization and thus cannot be considered as skin sensitizing.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data from various test chemicals
- Justification for type of information:
- Data is summarized based on the available information from various test chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on 2 skin sensitization studies as- WoE-2 and WoE-3.
Skin sensitization of test chemical was determined by mouse local lymph node assay (LLNA). - GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals and environmental conditions:
- not specified
- Vehicle:
- other: 2. not specified 3. propylene glycol
- Concentration:
- 2. 5 %, 10 %, and 25 % of the test substance (w/w)
3. concentrations 2.5%, 5%, 10%,25% and 50% - No. of animals per dose:
- 2. No data available
3. 20 (5 groups of 4 animals) - Details on study design:
- 2. No data available
3. TREATMENT PREPARATION AND ADMINISTRATION: Five groups of 4 animals were exposed to the test substance on 3 consecutive days (concentrations 2.5%, 5%, 10%, 25% and 50%) in parallel with a negative control group receiving the vehicle propylene glycol and a positive control group receiving the moderate sensitiser alpha-hexylcinnamaldehyde. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- not specified
- Statistics:
- 2. No data available
3. Not specified - Positive control results:
- 2. No data available
3. A significant lymphoproliferation was noted in the positive control given alpha-hexylcinnamaldehyde. The study was therefore considered valid - Parameter:
- SI
- Remarks:
- 2
- Value:
- 1.3
- Test group / Remarks:
- test group
- Remarks on result:
- other: at concentration of 5%
- Parameter:
- SI
- Remarks:
- 2
- Value:
- 1.5
- Test group / Remarks:
- test group
- Remarks on result:
- other: at concentration of 10%
- Parameter:
- SI
- Remarks:
- 2
- Value:
- 1.2
- Test group / Remarks:
- test group
- Remarks on result:
- other: at concentration of 25%
- Parameter:
- SI
- Remarks:
- 3
- Value:
- < 3
- Test group / Remarks:
- 4 animals
- Remarks on result:
- other: The Stimulation Index was below 3 (range: 1.01 to 1.79)
- Cellular proliferation data / Observations:
- 2. the chemical did not have sensitizing effects up to concentrations of 25%
3. The Stimulation Index was below 3 (range: 1.01 to 1.79) and no dose response reaction was observed. No systemic clinical signs and mortality, neither changes in body weight, nor local irritation was observed for all tested concentrations. - Interpretation of results:
- other: Not Sensitizing
- Conclusions:
- Based on the result obtained from the studies available for the structurally similar read across chemicals, it can be concluded that the test chemical cannot cause skin sensitization and thus cannot be considered as skin sensitizing.
- Executive summary:
The skin sensitization potential was assessed based on the available results from the various test chemicals.These studies have been summarized as below -
A mouse local lymph node assay (LLNA) was conducted for test chemical to determine its sensitizing effects. In this study, the application of 5%, 10% and 25% test chemical resulted in stimulation indices of 1.3, 1.5 and 1.2, respectively. Thus, a tripling of the lymphocyte stimulation was not reached with any of the test concentrations. Since, the chemical did not have sensitizing effects up to concentrations of 25%, it was considered as not sensitizing.
The above study was supported with another local lymph node assay performed to detect the delayed contact hypersensitivity in mice according to the OECD guideline 429 and to the EU Method B.42 for the given test chemical. Five groups of 4 animals were exposed to the test substance on 3 consecutive days (concentrations 2.5%, 5%, 10%, 25% and 50%) in parallel with a negative control group receiving the vehicle propylene glycol and a positive control group receiving the moderate sensitiser alpha-hexylcinnamaldehyde. After 2 days of resting, the animals were sacrificed in order to perform the proliferation assay. Changes in body weight, ear thickness were noted and the animals were checked on a regular base for clinical signs, mortality and local irritation. A significant lymphoproliferation was noted in the positive control given alpha-hexylcinnamaldehyde. The study was therefore considered valid. No noteworthy lymphoproliferation was noted with the test substance at any tested concentration. The Stimulation Index was below 3 (range: 1.01 to 1.79) and no dose response reaction was observed. No systemic clinical signs and mortality, neither changes in body weight, nor local irritation was observed for all tested concentrations. Since the test chemical failed to induce any contact sensitization effect in treated animals, it was considered as not sensitizing.
Based on the result obtained from the studies available for the structurally similar read across chemicals, it can be considered that the test chemical cannot cause skin sensitization and thus cannot be considered as skin sensitizing.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
The skin sensitization potential was assessed based on the available results from the various test chemicals.These studies have been summarized as below -
A mouse local lymph node assay (LLNA) was conducted for test chemical to determine its sensitizing effects. In this study, the application of 5%, 10% and 25% test chemical resulted in stimulation indices of 1.3, 1.5 and 1.2, respectively. Thus, a tripling of the lymphocyte stimulation was not reached with any of the test concentrations. Since, the chemical did not have sensitizing effects up to concentrations of 25%, it was considered as not sensitizing.
The above study was supported with another local lymph node assay performed to detect the delayed contact hypersensitivity in mice according to the OECD guideline 429 and to the EU Method B.42 for the given test chemical. Five groups of 4 animals were exposed to the test substance on 3 consecutive days (concentrations 2.5%, 5%, 10%, 25% and 50%) in parallel with a negative control group receiving the vehicle propylene glycol and a positive control group receiving the moderate sensitiser alpha-hexylcinnamaldehyde. After 2 days of resting, the animals were sacrificed in order to perform the proliferation assay. Changes in body weight, ear thickness were noted and the animals were checked on a regular base for clinical signs, mortality and local irritation. A significant lymphoproliferation was noted in the positive control given alpha-hexylcinnamaldehyde. The study was therefore considered valid. No noteworthy lymphoproliferation was noted with the test substance at any tested concentration. The Stimulation Index was below 3 (range: 1.01 to 1.79) and no dose response reaction was observed. No systemic clinical signs and mortality, neither changes in body weight, nor local irritation was observed for all tested concentrations. Since the test chemical failed to induce any contact sensitization effect in treated animals, it was considered as not sensitizing.
Based on the result obtained from the studies available for the structurally similar read across chemicals, it can be considered that the test chemical cannot cause skin sensitization and thus cannot be considered as skin sensitizing.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the result obtained from the studies available for the structurally similar read across chemicals, it can be concluded that the test chemical cannot cause skin sensitization and thus cannot be considered as skin sensitizing.
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