Registration Dossier
Registration Dossier
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EC number: 231-954-8 | CAS number: 7782-41-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption
Fuoride, rather than fluorine, is the agent that is toxicologically active systemically, since fluorine is too reactive to be absorbed unchanged. Fluorine is converted to fluoride, and then distribution and retention will follow the normal patterns for inorganic fluoride (WHO, 1984). The absorption of inorganic fluoride across mucous membranes is passive and is independent of the fluoride source.
No data were located regarding the absorption of fluorine in humans. Hepatic and renal effects were observed in mice following exposure to fluorine for periods up to 60 minutes (Keplinger and Suissa 1968). This indicates that the fluoride ion was systemically available following the exposure. Similarly, the finding of elevated fluoride levels in bones, teeth, and urine during intermediate-duration exposure to fluorine indicates that fluoride is absorbed under these conditions (Stokinger 1949).
Distribution
Absorbed fluoride is distributed primarily in the blood, 75% in the plasma and 25% associated with erythrocytes. Half of the plasma fluoride may be bound to organic molecules. Fluoride is rapidly distributed and is sequestered in the bones and teeth, where exchange with hydroxyl groups results in incorporation into the bone and tooth structure. Levels of fluoride in bones and teeth are directly correlated with exposure levels.
Excretion
Fluoride is excreted rapidly as a consequence of glomerular filtration, with a plasma half-life of 2-9 hours. The half-life for skeletal fluoride in humans is reported to be 8-20 years.
World Health Organisation (WHO) (1984). Fluorine and fluorides (Environmental Health Criteria 36). Geneva: International Programme on Chemical Safety.
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