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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
- Author:
- D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat , I.G. Sipes
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology, Vol. 50, Pg. no. S52-S99, 2012.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation study was conducted to assess the eye irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on three rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methoxybenzyl alcohol
- EC Number:
- 210-296-5
- EC Name:
- 2-methoxybenzyl alcohol
- Cas Number:
- 612-16-8
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2-methoxybenzyl alcohol
Constituent 1
- Specific details on test material used for the study:
- CAS No: 612-16-8
Name: 2-Methoxybenzyl alcohol
EC No.: 210-296-5
Substance type:Organic
Physical state:Liquid
smiles:O(c1c(cccc1)CO)C
InChI:1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No Data
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- 7 days
- Duration of post- treatment incubation (in vitro):
- no data
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- No data
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- definite conjunctival irritation, not clear until day 7
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test material 2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be irritating to the rabbits’ eye.
- Executive summary:
An eye irritation study was conducted to assess the eye irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on three rabbits
The chemical was installed into the eye of each subjects at a dose of 0.1ml and later observed for ocular lesions.
Each treated rabbit showed definite conjunctival irritation which persisted until day 7.
Hence,the chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be irritating to the rabbits’ eye.
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