Bismuth chloride oxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

Higher doses tested. No tables with individual data included.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bismuth chloride oxide

EC Number:

232-122-7

EC Name:

Bismuth chloride oxide

Cas Number:

7787-59-9

Molecular formula:

BiClO

IUPAC Name:

chlorobismuthanone

Test material form:

solid

Specific details on test material used for the study:

The test substance was diluted to a formulation of 50% in water.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Females nulliparous and non-pregnant: Yes
- Weight at study initiation: 190 to 236 g (males); 190 to 225 g (females)
- Fasting period before study: Yes, over night prior dosing

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

1000, 1590, 2510, 3980, 6310, 10000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality and clinical signs at one, four, and 24 hours and once daily thereafter for a total of 14 days.
- Necropsy of survivors performed: Yes, on all animals which died during the study and on those sacrificed (chloroform overdose) at termination

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

discriminating dose

Effect level:

10 000 mg/kg bw

Based on:

test mat.

Mortality:

1590 mg/kg bw: One male died on day 8
10000 mg/kg bw: One female appeared depressed and hunched at 24 hours, and subsequently died

Clinical signs:

other: 1000 mg/kg bw: One male showed wheezing from day 5 to termination

Gross pathology:

The male rat that died during the study (1590 mg/kg bw) demonstrated dark red areas on all lobes of the lungs. The death of one female rat during the study (10,000 mg/kg bw) was attributed to accidental puncture during gastric intubation.

Any other information on results incl. tables

In the guideline comparable but non-GLP compliant acute oral toxicity test, the test substance was tested for acute oral toxicity with the following doses 1000, 1590, 2510, 3980, 6310 and 10000 mg/kg bw for male and female rats. For each dose and sex 5 animals were used. The test substance (a fomulation of 50%) was administrated undiluted. The animals were observed for a period of 14 days. One male rat died at the 1590 mg/kg level and one female rat died at the 10000 mg/kg level. The death at the higher dose was attributed to accidental puncture during gastric intubation.

In the present acute oral toxicity study an LD50 cut-off value of > 10000 mg/kg bw was found.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008

Conclusions:

CLP: not classified