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Diss Factsheets
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EC number: 946-843-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- yes
Test material
- Reference substance name:
- Saccharides from Saccharomyces Cerevisiae
- EC Number:
- 946-843-6
- IUPAC Name:
- Saccharides from Saccharomyces Cerevisiae
- Test material form:
- liquid
- Details on test material:
- yellow liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- Source: ESD - Romans 01400 Chatillon sur Chalaronne
Weight: about 2 to 2.5 kg at the time of trial
Acclimatation : At least 5 days in the animal shelter of the laboratoy
Housing: The animal are kept in individual metal cages of standardized dimensions with perforated floor. These cages are placed in a temperature controlled animal shelter where the temperature is between 18 and 22°C and the relative humidity is maintained between 30 and 80%.
Food: Extralabo C15 ETS PIETREMENT
Water: tap water provided ad libitum with automatic pipettes
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 0.1 ml of the product is administrated with a syringe. The eyelids of the animals are kept shut for about 10 seconds in order to avoid product loss. The eyes are not rinsed.
- Observation period (in vivo):
- Before the trial, the ocular mucose of each rabbit is examined in order to eliminate any animal presenting lesions.
The rabbits are restrained on the day of the trial. The product is instilled and the animals are restrained for our hour until the first examination is carried out. The animals are then returned in their cages.
The following eyes examinations are carried out on immobilized rabbits every day until day 7.
The observations are completed on day 3 if the ocular lesions have disappeared.
The examination is made in the following order: conjunctiva, pupli, cornea. - Number of animals or in vitro replicates:
- 3 rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test item does not provide any specific irritant lesions of ocular mucose in the experimental conditions employed.
- Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item does not provide any specific irritant lesions of ocular mucose in the experimental conditions employed.
- Executive summary:
An in vivo study was performed on New Zealand albino rabbit according to OECD guidelines number 405 of February 24, 1987 and EEC guidelines 67/548.
The test item was intilled in the formix of the conjunctiva of 3 rabbits, by a 0.1 ml dosage. The eye was not rinsed.
In order to rate chemical product in accordance with EEC guidelines 67/548, a mean irritation index was calculated for each animal.
The test item does not provide any specific irritant lesions of ocular mucose in the experimental conditions employed.
In these conditions, the product is rated as non irritant.
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