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Diss Factsheets
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EC number: 266-019-3 | CAS number: 65996-85-2 The reaction product obtained by neutralizing coal tar oil alkaline extract with an acidic solution, such as aqueous sulfuric acid, or gaseous carbon dioxide, to obtain the free acids. Composed primarily of tar acids such as phenol, cresols, and xylenols.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 471 with acceptable restrictions (not tested in TA 1535; no data about purity of the test substance or cytotoxic effects)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- (TA1535 not tested)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
- Details on test material:
- BATCH: N2B
DATE OF PRODUCTION: 04.11.2008
no further details
Constituent 1
Method
- Target gene:
- His-
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97a, TA98, TA100, TA102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix of male rats treated with 500 mg/kg bw Delor103 five days prior to sacrifice
- Test concentrations with justification for top dose:
- The substance was applied directly to the petri dish in the following amounts: 0, 5, 10, 20, 40, 80 µL
- Vehicle / solvent:
- water
Controls
- Untreated negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminofluorene with S)-mix & furylfuramid without S9-mix
- Details on test system and experimental conditions:
- The substance in quantities of 0.1 ml with 2 - 4 x 10E7 fresh cells of each strain was added to sterile tubes with 2 ml of top agar with histidine and biotin. In tests with metabolic activation, 0.5 ml of metabolic activation mixture was added to each tube. The content of the tube poured onto the surface of glucose minimal medium, deposited on a Petri dish (PD). Petri dishes were incubated at 37 ° C for 48-72 hours. Subsequently, his + revertant colonies were counted. Tests were repeated three times at each concentration on two parallel Petri dishes
- Evaluation criteria:
- statistical significance
- Statistics:
- The observed values were statistically evaluated by a system of one-dimensional data set (Student t - test): the arithmetic mean, standard deviation and statistical significance.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other:
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Authors conclusion: "The test substance did not show statistically significant increase in revertants in the Ames test, depending on the doses - concentration used. The negative response in the experiments show that in the test conditions Phenol does not have mutagenic properties to the target indicator Salmonella typhimurium."
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Negative results in the Ames test with and without metabolic activation even at very high concentrations up to 80 µL/plate
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