Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-234-5 | CAS number: 67827-72-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB for the CAS: 121-89-1
- Author:
- US National Library of Medicine reviewed by SRC
- Year:
- 2 002
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US National Library of Medicine reviewed by SRC;last updated 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The ocular irritation potential of 3- nitroacetophenone was assessed in rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3'-nitroacetophenone
- EC Number:
- 204-504-3
- EC Name:
- 3'-nitroacetophenone
- Cas Number:
- 121-89-1
- Molecular formula:
- C8H7NO3
- IUPAC Name:
- 1-(3-nitrophenyl)ethanone
- Reference substance name:
- 3-nitroacetophenone
- IUPAC Name:
- 3-nitroacetophenone
- Test material form:
- solid
- Details on test material:
- Name of test material (as cited in study report): 3 nitro acetophenone
Molecular formula : C8H7NO3
Molecular weight: 165.147 g/mol
Smiles notation : c1(cc(ccc1)[N+](=O)[O])C(C)=O
InChl : 1S/C8H7NO3/c16(10)73248(57)9(11)12/h25H,1H3
Substance type: Organic
Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Name of test material (as cited in study report): 3- nitroacetophenone
Molecular formula : C8H7NO3
Molecular weight: 165.147 g/mol
Smiles notation : c1(cc(ccc1)[N+](=O)[O])C(C)=O
InChl : 1S/C8H7NO3/c16(10)73248(57)9(11)12/h25H,1H3
Substance type: Organic
Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- SCORING SYSTEM: reactions were rated on scale of 1 to 10 according to degree of injury observed
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Grade 1 injury means not irritating , grade 10 injury means severely irritating to eyes.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The ocular irritation potential of 3- nitrocetophenone was assessed in rabbits.
3- nitroacetophenone was rated 1 on scale of 1 to 10 according to degree of injury observed after 24 hr. The most severe injuries have been rated 10.
Therefore, 3- nitroacetophenone can be considered to be not irritating to rabbit eyes. - Executive summary:
The ocular irritation potential of 3- nitroacetophenone was assessed in rabbits.
The test chemical was instilled into rabbit eyes and effects were observed for 24 hours. The effects were graded on a scale 1-10 after 24 hours.
3- nitroacetophenone wasrated 1 on scale of 1 to 10 according to degree of injury observed after 24 hr. The most severe injuries have been rated 10.
Therefore,3- nitroacetophenone can be considered to be not irritating to rabbit eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
