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Diss Factsheets
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EC number: 918-205-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
not sensitising (OECD429/EU B.42, GLP, read-across from structural analogue)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substance have similar skin sensitising properties because they share structural similarities with common functional groups. Source as well as target substance are both alkyltriphenylphosphonium halogen salts. The alkyltriphenylphosphonium moiety of source and target is almost identical, differing only in the length of the saturated linear alkyl chain (ethyl instead of n-butyl). The counterion is identical - bromide.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source Target
Name Ethyltriphenylfosfonium bromide n-Butyltriphenylphosphonium bromide
CAS 1530-32-1 1779-51-7
EC 216-223-3 217-219-4
Common functional group 1 Triphenylphosphonium Triphenylphosphonium
Common functional group 2 counterion bromide counterion bromide
Deviating functional group alkyl chain ethyl alkyl chain butyl
Purity Please refer to section ´Confidential details in general comparable to source substance
on test material´ of the respective source substance ID.
3. ANALOGUE APPROACH JUSTIFICATION
The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both alkyltriphenylphosphonium salts with an identical counterion, bromide. As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, this read-across is justified. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- SI
- Value:
- 1
- Test group / Remarks:
- 1 and 2.5% source substance
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Read-across data used. The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both alkyltriphenylphosphonium salts with an identical counterion, bromide. As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, this read-across is justified.
In an in vivo dermal sensitisation study (Local Lymph Node assay according toEU Method B.42 (2004),OECD guideline 429 (2002) andEPA OPPTS 870.2600(2003)), source substanceEthyltriphenylfosfonium bromide revealed no sensitising activity.Because of this result, n-Butyltriphenylphosphonium bromide in all probability has also no sensitising activity.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In an in vivo dermal sensitisation study (Local Lymph Node assay) Ethyltriphenylfosfonium bromide revealed no sensitising activity.
As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, n-Butyltriphenylphosphonium bromide in all probability has also no sensitising activity.
According to the criteria of REGULATION (EC) No 1272/2008, n-Butyltriphenylphosphonium bromide does not have to be classified and has no obligatory labelling requirement for sensitization by skin contact.
According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2004), n-Butyltriphenylphosphonium bromide does not have to be classified for sensitization by skin contact.
n-Butyltriphenylphosphonium bromide is not classified for respiratory sensitisation because of lack of data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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