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EC number: 500-003-1 | CAS number: 9003-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
No ADME studies are available for tripropylene glycol n-butyl ether-highers (TPnB-highers) as such. Therefore, the toxicokinetics assessment is based on the available data for structurally related propylene glycol ethers (PGEs) such as propylene glycol methyl ether (PM), dipropylene glycol methyl ether DPM, tripropylene glycol methyl ether (TPM), propylene glycol n-butyl ether (PnB) and dipropylene glycol n-butyl ether (DPnB).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
No ADME studies are available for tripropylene glycol n-butyl ether highers (TPnB-highers) as such. Therefore, the toxicokinetics assessment is based on the available data for structurally related propylene glycol ethers (PGEs) such as propylene glycol methyl ether (PM), dipropylene glycol methyl ether DPM, tripropylene glycol methyl ether (TPM), propylene glycol n-butyl ether (PnB) and dipropylene glycol n-butyl ether (DPnB). As a class, the propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. Metabolism studies (by oral exposure) conducted with several PGEs support this conclusion. While not tested directly, absorption by inhalation exposure also would be expected to be rapid for PGEs aerosols that are in the respirable range. However, due to the low vapor pressure of TPnB-highers no inhalation exposure is expected for this substance. Dermal absorption is expected to be somewhat slower but, once absorbed, subsequent distribution also should be rapid. When a single dose of DPnB was administered orally to rats, most of the dose was eliminated within 48 hours indicating rapid excretion. Similar rapid absorption, distribution, and elimination occurred within 48 hours for TPM. Most excretion for PGEs is via the urine and expired air. A small portion is excreted in the feces. In analogy to PnB and DPnB the metabolism of TPnB-highers is expected to take place predominantly in the liver where mixed function oxidase cleaves the ether linkage, yielding propylene glycol and an alcohol. These two products may be further metabolised to CO2 and water, with the latter ultimately being excreted in expired air. Alternatively, TPnB-highers (or intermediate metabolites) may be conjugated in the liver with glucuronide, sulfate, or glutathione for ultimate excretion, predominantly in the urine. TPnB-highers is expected to be rapidly absorbed and distributed throughout the body when introduced by oral exposure. Dermal absorption is expected to be somewhat slower but subsequent distribution will be rapid.
Discussion on bioaccumulation potential result:
As a class, the propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. Metabolism studies (by oral exposure) conducted with several PGEs support this conclusion. While not tested directly, absorption by inhalation exposure also would be expected to be rapid for aerosols of PGEs that are in the respirable range. However, due to the low vapor pressure of TPnB-highers no inhalation exposure is expected for this substance. Dermal absorption is expected to be somewhat slower but, once absorbed, subsequent distribution also should be rapid. When a single dose of DPnB was administered orally to rats, most of the dose was eliminated within 48 hours indicating rapid excretion. Similar rapid absorption, distribution, and elimination occurred within 48 hours for TPM. Most excretion for PGEs is via the urine and expired air. A small portion is excreted in the feces. In analogy to PnB and DPnB the metabolism of TPnB-highers is expected to take place predominantly in the liver where mixed function oxidase cleaves the ether linkage, yielding propylene glycol and an alcohol. These two products may be further metabolised to CO2 and water, with the latter ultimately being excreted in expired air. Alternatively, TPnB-highers (or intermediate metabolites) may be conjugated in the liver with glucuronide, sulfate, or glutathione for ultimate excretion, predominantly in the urine. TPnB-highers is expected to be rapidly absorbed and distributed throughout the body when introduced by oral exposure. Dermal absorption is expected to be somewhat slower but subsequent distribution will be rapid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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