Registration Dossier
Registration Dossier
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EC number: 259-502-5 | CAS number: 55150-29-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of Chroman-4-one (CAS no: 491-37-2) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute oral toxicity of Chroman-4-one (CAS no: 491-37-2) in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Chroman-4-one
- EC Number:
- 207-736-3
- EC Name:
- Chroman-4-one
- Cas Number:
- 491-37-2
- Molecular formula:
- C9H8O2
- IUPAC Name:
- Chroman-4-one
- Details on test material:
- - Name of test material (as cited in study report):Chroman-4-one
- Molecular formula (if other than submission substance):C9H8O2
- Molecular weight (if other than submission substance):148.1602 g/mole
- Substance type:Organic
- Physical state:No data
- Smiles: c1ccc2c(c1)C(=O)CCO2
- InChI: 1S/C9H8O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-4H,5-6H2
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Chroman-4-one
- Molecular formula (if other than submission substance):C9H8O2
- Molecular weight (if other than submission substance):148.1602 g/mole
- Substance type:Organic
- Physical state:No data
- Smiles: c1ccc2c(c1)C(=O)CCO2
- InChI: 1S/C9H8O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-4H,5-6H2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2647 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: Animals were observed for clinical signs.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 647 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 2647 mg/kg bw.
- Clinical signs:
- other: Clinical signs such as, ataxia and gastrointestinal examination revels, hyper motility and diarrhea in animals. Animals were exhibit Chromodacyrorrea (Red lacrimal secretion).
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was considered to be 2647 mg/kg bw, when rats were treated with Chroman-4-one (CAS no: 491-37-2) via oral route.
- Executive summary:
The acute oral toxicity of Chroman-4-one (CAS no: 491-37-2) was tested inrats at the dose concentration of 2647 mg/kg bw. Animals were observed for clinical signs. 50% mortality was observed at 2647 mg/kg with clinical signs such as, ataxia, hyper motility in GIT, diarrhoea and Chromodacyrorrea. Therefore, LD50 was considered to be 2647 mg/kg bw, when rats were treated with Chroman-4-one via oral route.
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