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EC number: 204-671-2 | CAS number: 124-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion:
A weight of evidence approach has been taken based on four seperate
tests (two in rats and two in rabbits).
Tests in rats:
-In rats (strain and age not provided), application of 0.1 mL of diallylamine to a 1 cm2 area of shaved abdominal skin caused severe necrosis and death.
-In rats (strain and age not provided), application of 0.1 mL of diallylamine for 1 hour under a patch caused severe necrosis followed by death.
Application of 0.05 mL had no effects.
Tests in rabbits:
-Diallylamine was corrosive on intact rabbit skin (strain, age and dose not provided) exposed for 4 hours and observed for 4, 24 and 48 hours after treatment. Severe necrosis was present at all observation points.
-Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material (0.5 ml) under a patch.
The outcome of all available reults showed diallylamine to be corrosion to skin (rat and rabbit).
Eye irritation:
Two available tests in rabbit eyes have been used in the assessment of eye irritation.
-In rabbits (strain and age not specified), application of 50 mg diallylamine to the eyes was severely irritating. Eyes were rinsed for 20 seconds following exposure, but the duration of exposure was not specified.
-In six New Zealand White rabbits, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application of 0,1 mL diallylamine into one eye.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.
Based on this data the substance is considered to be a corrosive/severely irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 mL applied to 1cm2 area
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Purity not provided.
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- rat strain and age not specified
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL applied to 1 cm2 area of shaved abdominal skin.
- Duration of treatment / exposure:
- Single application
- Observation period:
- Not provided
- Number of animals:
- Not provided
- Remarks on result:
- other: Severe necrosis and death
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Exposure caused severe necrosis and death, but the incidence of mortality was not provided.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Exposure caused severe necrosis and death.
- Executive summary:
In rats (strain and age not provided), application of 0.1 mL of diallylamine to a 1 cm2 area of shaved abdominal skin caused severe necrosis and death.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.05 and 0.1 ml/sq.cm. substance applied for 1 hour under patch
- GLP compliance:
- no
- Specific details on test material used for the study:
- Purity not provided.
- Species:
- rat
- Strain:
- not specified
- Type of coverage:
- other: under patch
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.05 ml and 0.1 ml
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- Not specified
- Number of animals:
- Not specified.
- Irritation parameter:
- other: necrosis
- Basis:
- other: 0.10 ml application
- Remarks on result:
- other: Severe necrosis followed by death
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: necrosis
- Basis:
- other: 0.05 ml application
- Remarks on result:
- no indication of irritation
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Severe necrosis at 0.10 ml.
No effect at 0.05 ml. - Other effects:
- Death at 0.10 ml
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Severe necrosis at 0.10 ml.
- Executive summary:
In rats (strain and age not provided), application of 0.1 mL of diallylamine for 1 hour under a patch caused severe necrosis followed by death.
Application of 0.05 mL had no effects.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Purity not provided.
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Rabbit strain and age not provided.
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Amount applied not provided.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observations were made 4, 24, 48 hours after treatment.
- Number of animals:
- 6
- Irritation parameter:
- other: necrosis
- Basis:
- other: all rabbits
- Time point:
- other: 4, 24 and 48 hours
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive
- Remarks:
- severe necrosis. This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Diallylamine was corrosive and caused severe necrosis in the skin of all rabbits at all observation times.
- Other effects:
- Mortality data not provided.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Diallylamine was corrosive and caused severe necrosis in the skin of all rabbits at all observation times.
- Executive summary:
Diallylamine was corrosive on intact rabbit skin (strain, age and dose not provided) exposed for 4 hours and observed for 4, 24 and 48 hours after treatment. Severe necrosis was present at all observation points.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Purity not provided
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- other: under patch
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 3 minute and 1 hour exposure
- Observation period:
- not specified
- Number of animals:
- 6 (3 per exposure)
- Irritation parameter:
- other: corrosion
- Basis:
- other: all animals
- Time point:
- other: 3 minute exposure
- Remarks on result:
- other: Corrosive
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: corrosion
- Basis:
- other: all animals
- Time point:
- other: 1 hour exposure
- Remarks on result:
- other: Corrosive
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Corrosive to skin at either exposure time.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material under a patch.
- Executive summary:
Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material (0.5 ml) under a patch.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 mL diallylamine was applied into one eye of rabbit. Observations were made 1, 2, 3 and 7 days after dosing.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Purity not provided.
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age and sex of rabbits not specified.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single dose.
- Observation period (in vivo):
- Observations were made 1, 2, 3 and 7 days after dosing.
- Number of animals or in vitro replicates:
- 6 rabbits.
- Irritation parameter:
- other: corneal damage
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: severe corneal damage
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: chemosis
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: chemosis (edema of the bulbar conjunctiva)
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: conjunctiva
- Remarks:
- (discharge)
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: discharge of the conjunctivae
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: erythema
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: severe erythema
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Severe corneal damage, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment. - Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Severe corneal damage was observed. In the conjunctivae, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge were observed. There were no signs of remission 7 days after treatment.
- Executive summary:
In six New Zealand White rabbits, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application of 0,1 mL diallylamine into one eye.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Diallylamine was applied to rabbits eyes. Eyes were rinsed 20 seconds following exposure.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Purity not provided.
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Rabbits strain and age not specified.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 50 mg (0.52 mmol)
- Duration of treatment / exposure:
- Eyes were rinsed 20 seconds following exposure, but the duration of exposure was not specified.
- Observation period (in vivo):
- Not specified
- Remarks on result:
- other: Diallylamine was severly irritating
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Interpretation of results:
- other: severely irritating
- Conclusions:
- Diallylamine was severly irritating to rabbit eyes.
- Executive summary:
In rabbits (strain and age not specified), application of 50 mg diallylamine to the eyes was severely irritating. Eyes were rinsed for 20 seconds following exposure, but the duration of exposure was not specified.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No highly reliability data is available for respiratory irritation. However, as the substance is corrosive and inhalation is a possible exposure route, it is a reasonable assumption that the substance may also cause respiratory tract irritation when inhaled.
Justification for classification or non-classification
Skin corrosion:
Based on the available data the substance is corrosive to skin and shall be classified as a skin corrosive Category 1; H314: Causes severe skin burns and eye damage.
A sub-category classification of 1B has been assigned based on the weight of evidence study data.
This has been considered appropriate as from the available data there is conclusion evidence for corrosion after 1 hour exposure.
A corrosive result from a 3 minute exposure is available but there are no details on whether the corrosive effects were observed within 1 hr, so it is considered classification as sub-category 1A cannot be conclusively assigned.
Eye irritation:
Based on the available data the substance is considered to be corrosive to eyes and shall be classified as having irreversible effects on the eye, Category 1; H318: Causes serious eye damage.
In addition, skin corrosives can be assumed to be corrosive to eyes.
STOT-SE 3 (Respiratory tract irritaiton):
Respiratory tract irritaiton may be assumed to present a hazard but the classification for corrosivity is considered to implicitly cover the potential to cause RTI and so an additional classification for STOT-SE 3 is considered to be superfluous.
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