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EC number: 201-719-4 | CAS number: 87-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute Dermal toxicity of Resorcinol (108-46-3).
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
- Reference Type:
- other:
- Title:
- Acute Dermal toxicity of Resorcinol (108-46-3).
- Author:
- Hazardous Substances Data Bank
- Year:
- 2 017
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017.
- Reference Type:
- review article or handbook
- Title:
- Acute Dermal toxicity of Resorcinol.
- Author:
- World Health Organization
- Year:
- 2 006
- Bibliographic source:
- World Health Organization, International Programme on Chemical Safety (IPCS), United Nations Environment Programme (UNEP), 2006
- Reference Type:
- secondary source
- Title:
- Reports by the Scientific Committee on Cosmetology on the Use of Certain Hair Dyes
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 993
- Bibliographic source:
- Opinion of the Scientific Committee on Cosmetology (11/86 - 10/90), European Commission (EC) - Scientific Committee on Cosmetology (SCC), 1993.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute Dermal toxicity of Resorcinol (108-46-3) in Rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Resorcinol
- Cas Number:
- Resorcinol
- Molecular formula:
- C6H6O2
- IUPAC Name:
- Resorcinol
- Details on test material:
- - Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 1000, 2000 and 3360 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: Animal was observed for clinical signs, body weight and Gross pathology.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 360 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50% morality was observed at 3360 mg/kg bw
- Clinical signs:
- other: At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure.
- Gross pathology:
- At ≥2000 mg/kg body weight - skin necrosis but no gross lesions was seen in treated rabbits.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.
- Executive summary:
The acute dermal toxicity study was conducted by using Resorcinol in male rabbits at the concentration of 1000, 2000 and 3360 mg/kg bw for 24 h applied by topically. Animals were observed for clinical signs, body weight and Gross pathology. 50% morality was observed in rabbits at 3360 mg/kg along with clinical signs such as - At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure. At ≥2000 mg/kg body weight - skin necrosis was seen in treated rabbits.Body weight loss was observed at 1000 mg/kg. No gross lesions were observed at 1000 mg/kg body weight. Therefore, LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.
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