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EC number: 222-326-4 | CAS number: 3426-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD20 = 3300 mg/kg bw
LD50 > 3300 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
The acute oral toxicity of the substance was assessed using a test sample with composition: 33 % OB 134, 38 % water and coupage as for the remaining. Based on information reported in study reports, the sample is liquid.
OB 134 was administered to rats (5 dose/sex) at doses of 4640, 7750, 9000 and 10000 mg/kg, causing death on 1 rat/sex only in the high dose group within 24 hours from dosing. A 14 -day observation period followed dosing.
Further studies were available and are summarised in the table below:
test material | composition | method | results | date |
FAT 65006/E | 33 % a.i., 38 % water, coupage | 5 rabbit/sex/dose; 30 % concentration of formulation; 4640, 6000, 7750 mg/kg test material; 14-day observation period | LD0 = 7750 mg/kg LD0 = 2558 mg/kg (a.i.) |
1976 |
Rylux PRS | 70 - 80 % a.i, 20 - 30 % non coloured components | 20 % suspension in olive oil, rats | LD20 = 15850 mg/kg LD20 = 11888 mg/kg (a.i.) LD50 > 15850 mg/kg |
1980 |
The first study followed the same test procedure as the key study; however, physical state of test sample was solid. Few details on test procedure and results were available on the second study. Overall, available data indicated low toxicity of OB 134 by acute oral exposure.
A study on acute inhalation toxicity of OB 134 was also available. It was conducted as limit test: 10 rats were exposed to test substance for 4 hours in the inhalation chamber at concentration of 5 mg/l. In the 14 -day observation period, no treatment related deaths were reported; effects were found to be reversible and no macroscopic changes were noted at necropsy. Therefore, LC0 = 5 mg/l and no LC50 could be established.
Data on acute dermal toxicity to rats also available. No signs of intoxication were noted; rats were killed 14 days upon application and no macroscopic changes were detected in the organs.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
The oral LD50 value was established to be greater than 2000 mg/kg bw, therefore the test substance is above the classification threshold for acute oral toxicity (Category 4: 300 < ATE ≤ 2000 mg/kg).
The dermal LD50 value was found to be above 5000 mg/kg bw, thus above the classification threshold for acute dermal toxicity (Category 4: 1000 < ATE ≤ 2000 mg/kg).
The inhalation LC50 value was found to be above 5 mg/l, thus above the classification threshold for acute inhalation toxicity of dust (Category 4: 1.0 < ATE ≤ 5.0 mg/l).
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