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EC number: 208-341-9 | CAS number: 523-24-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 10 June 2005 and 11 August 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
Test material
- Reference substance name:
- Diammonium phthalate
- EC Number:
- 208-341-9
- EC Name:
- Diammonium phthalate
- Cas Number:
- 523-24-0
- Molecular formula:
- C8H6O4.2H3N
- IUPAC Name:
- diammonium phthalate
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Description: white crystalline solid
Lot number: 4172005
Date recieved: 02 June 2005
Storage conditions: room temperature, in the dark - Radiolabelling:
- no
Study design
- Test temperature:
- 30°C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
HPLC system: Agilent Technologies 1100, incorporating autosampler and workstation
Column: Genesis CN 120A 4 μm (250 x 4.6 mm id)
Column temperature: 30°C
Flow-rate: 1 ml/min
UV detector wavelength: dead time and reference standards: 210 nm
sample: 228 nm
MOBILE PHASES
- Type: methanol:reverse osmosis water (55:45 v/v) adjusted to pH 7 .0 with 0.1 M hydrochloric acid and approximately 0.1% pH 7 buffer solution*
- pH: approzimately neutral
- Solutes for dissolving test and reference substances: reverse osmoisis water and methanol for test and reference substances respectively
* pH 7 buffer solution composition: disodium hydrogen orthophosphate (0.03 M), potassium dihydrogen orthophosphate (0.02 M) and sodium chloride (0.02 M)
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity
>99.5%, 765 mg/I solution in methanol).
REFERENCE SUBSTANCES
- Identity:
Acetanilide
Phenol
Isoproturon
Triadimenol
Linuron
Naphthalene
Endosulfan-diol
Fenthion
a-Endosulfan
Phenanthrene
Diclofop-methyl
DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 μl
- Quantity of reference substances: 10 μl
REPETITIONS
- Number of determinations: 2
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- < 1.25 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Remarks on result:
- other: phthalate component
- Type:
- log Koc
- Value:
- < 1.25 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Remarks on result:
- other: ammonium component
Results: HPLC method
- Details on results (HPLC method):
- Adsorption coefficient of sample
The retention times, capacity factors and log10 Koc values determined for the sample are shown in the following table:
Injection Retention time (mins) Capacity Factor (k) Log10k Log10koc
1 1.807 < 0.213 < -0.671 < 1.25
2 1.809 < 0.213 < -0.671 < 1.25
Mean log10 Koc: < 1.25
Adsorption coefficient: < 17.8
Discussion
The method guideline states that the measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However, the dissociation constants of certain functional groups found in the test material made it impossible to satisfy this criteria. Testing would be required at pH 3 or below and at greater than pH 11 for the acidic and basic functional groups respectively. As a consequence of this, one of the functional groups will always be present in its ionised form. Therefore, as these pHs are outside the environmental pH range for this test and also experimentally impractical, testing was carried out at approximately neutral pH with both functional groups ionised.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficients (Koc) of components of the test material have been determined. The results are shown in the following table:
Component Log10Koc Koc
Phthalate < 1.25 < 17.8
ammonium < 1.25 < 17.8 - Executive summary:
The adsorption coefficients (Koc) of the components of the test material were determined using the HPLC screening method, Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. Thre results are as follows:
Component
Log10Koc
Koc
Phthalate
< 1.25
< 17.8
ammonium
< 1.25
< 17.8
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