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EC number: 203-470-7 | CAS number: 107-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- skin irritation in-vivo: slightly irritating to the skin of male rabbits (Dunlap, 1958)
- eye irritation in-vivo: irritating to the eyes of rabbits (Jacobs, 1988/1992; Dunlap,1958)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed journal
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 2-Propen-1-ol (0.5ml) was applied to intact and abraded skin (ventral surface) of 3 male albino rabbits. (It is not stated if fur at the treatment site was clipped first.) The application site was covered with gauze under a rubber dam, fastened with adhesive tape.
The test site was examined 24 hr post-application. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- exposure time: 24 h
- Observation period:
- no data
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- other: animal #1 (of 3 animals)
- Time point:
- 24 h
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Slight erythema was present at the application site (intact skin) of one animal.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Under the conditions of this test, 2-propen-1-ol was slightly irritating to rabbit skin.
Reference
Slight erythema was present at the application site (intact skin) of one animal when the patch was removed (24 hr timepoint) but this had fully resolved by 48 hr. No other reactions were noted.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Draize Test
- Deviations:
- not specified
- Principles of method if other than guideline:
- 2-Propen-1-ol (0.05 ml) was instilled into the left eye of 3 male albino rabbits.
The eyes were examined after 1 hr for signs of irritation (first unstained, then after application of 5% fluorescein sodium). Further examinations were carried our at 24 hr and 48 hr and during the subsequent week. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 1 h
- Observation period (in vivo):
- 1hr, 24 hr and 48 hr
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- other: Conjunctival erythema
- Time point:
- other: 1 hr
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 3/3 rabbits
- Irritation parameter:
- other: edema
- Time point:
- other: 1 hr
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 1/3 rabbits
- Irritation parameter:
- other: conjunctival erythema
- Time point:
- other: 24 h
- Score:
- > 4 - < 6
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 3/3 rabbits
- Irritation parameter:
- other: corneal opacity
- Time point:
- other: 24 h
- Score:
- > 5 - < 10
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 2/3 rabbits
- Irritation parameter:
- other: iris
- Time point:
- other: 24 h
- Score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 1/3 rabbits
- Irritation parameter:
- other: conjunctival redness
- Time point:
- other: 48 h
- Score:
- > 2 - < 6
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 3/3 rabbits
- Irritation parameter:
- other: corneal opacity
- Time point:
- other: 48 h
- Score:
- 5
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: affecting 1/3 rabbits
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the conditions of this test, 2-propen-1-ol was irritating to rabbit eye producing reversible conjunctival redness, iridial injection and corneal opacity that persisted at least 48 hr post instillation.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed journal
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- score of iris was not recorded
- Principles of method if other than guideline:
- The test was carried out in two phases with rabbits, seperated by about 6 months. In the first phase, the rabbits were tested and scored clinically. In the second phase in addition to the clinical examination corneal swelling was also measured using a ultrasonic pachometer.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 1 s (single application of test material)
- Observation period (in vivo):
- 4, 24, 48, 72, 96 and 168 h
- Number of animals or in vitro replicates:
- 6 (3 in the first phase and 3 additional in the second)
- Irritation parameter:
- other: erythema
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 2.89
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: 6 rabbits
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 1.23
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: 6 rabbits
- Irritation parameter:
- other: corneal opacity
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 2.09
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: 6 rabbits
- Irritation parameter:
- other: Corneal swelling thickness
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 76
- Max. score:
- 100
- Reversibility:
- not specified
- Remarks on result:
- other: 3 rabbits
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the conditions of this study, allyl alcohol is considered to be irritating in the eyes of rabbits.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 96 h
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24/48/72 hrs
- Score:
- > 2.5
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24/48/72 hrs
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- other: corneal opacity
- Basis:
- mean
- Time point:
- other: 24/48/72 hrs
- Score:
- 2.07
- Max. score:
- 4
- Reversibility:
- not specified
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- irritating
Referenceopen allclose all
Compound Tested: 2-Propenol; (RN) 107-18-6; Ally1 alcohol
Compound Preparation: Neat
Time after application | 4 Hr | 24 Hr | 48 Hr | 72 Hr | 96 Hr |
Mean Score of Conjunctivitis (3 maximum) | 1.9 | 2.7 | 3.0 | 2.9 | 2.8 |
Mean Score of Chemosis (4 maximum) | 1.7 | 1.5 | 1.0 | 0.3 | 0.3 |
Mean Score of Iritis (2 maximum) | 1.0 | 1.0 | 1.0 | 1.0 | 0.7 |
Mean Score of Corneal Opacity (4 maximum) | 1.2 | 1.7 | 2.2 | 2.3 | 2.5 |
Mean Surface of Corneal Damage (100% maximum) | 90 | 84 | 56 | 25 | 28 |
Classification according to the EC criteria in EEC (1983). Annex VI, part IID of the Council directive 79/831/EEC (19 September 1983, Irritating to eyes (mean of conjunctivitis over 24/48/72 Hrs > 2.5, mean of iritis over 24/48/12 Hrs = 1, mean of corneal opacity over 24/48/72 Hrs >2)
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H315: causes skin irritation.
The CLP classification is in accordance with the one listed for Allyl alcohol in Annex VI (EC No. 1272/2008).
Eye irritation: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H319: causes serious eye irritation.
The CLP classification is in accordance with the one listed for Allyl alcohol in Annex VI (EC No. 1272/2008).
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