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EC number: 204-567-7 | CAS number: 122-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity studies with insect attractants
- Author:
- Morton Berozaa, M.N. Inscoea, , P.H. Schwartz Jr.a, M.L. Keplingera, C.W. Mastria
- Year:
- 1 975
- Bibliographic source:
- Toxicology and Applied Pharmacology, Volume 31, Issue 3, March 1975, Pages 421–429
- Reference Type:
- publication
- Title:
- A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients
- Author:
- D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology, 50 (2012) S269–S313
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An ocular irritation study was conducted for 2-phenylethyl propanoate (CAS No: 122-70-3) on six New Zealand albino rabbits to assess its adverse effects on eye.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl propionate
- EC Number:
- 204-567-7
- EC Name:
- Phenethyl propionate
- Cas Number:
- 122-70-3
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 2-phenylethyl propanoate
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 2-phenylethyl propanoate
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-phenylethyl propanoate
- Common name: Phenethyl propionate (PEP)
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- Weight at study initiation: 1.9-3.1 kg
Test system
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- concentration applied :70%
Amount : 0.1 ml per dose - Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 1,24,48, 72 hours and 7 days
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: conjunctival sac of right eye of each animal.
SCORING SYSTEM: According to the grading and scoring system of Draize et al. (1944) in which a zero score indicates no irritation and the maximum score at any one scoring period is 110 (maximum irritation and damage to the cornea, iris, and conjunctiva).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Slight ocular lesions were observed but all the effects were reversible within 3 days.
Any other information on results incl. tables
Table 1: Primary Irritation score in rabbits
Time Point |
Primary Irritation Score |
1 hour |
12 |
24 hour |
7.5 |
48 hours |
4.6 |
72 hours |
0 |
7 days |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The mean irritation score of chemical 2-phenylethyl propanoate (CAS No: 122-70-3) was observed to be 0.0 after 72 hours. Therefore chemical 2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating to the eyes of six New Zealand albino rabbits.
- Executive summary:
An ocular irritation study was conducted for 2-phenylethyl propanoate (CAS No: 122-70-3) on six New Zealand albino rabbits to assess its adverse effects on eye.
The 0.1ml dose of 70% 2-phenylethyl propanoatewas installed into the conjunctival sac of the right eye of each of six rabbit while the left eye of each animal served as the control.
Grading for eye injury was made at 1 , 24, 48 and 72 hr and at 7 days after treatment according to the grading and scoring system of Draize et al. (1944) in which a zero score indicates no irritation and the maximum score at any one scoring period is 110 (maximum irritation and damage to the cornea, iris, and conjunctiva).
Slight ocular lesions were observed but all the effects were cleared within 3 days. Hence the chemical 2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating to the eyes of six New Zealand albino rabbits.
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