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EC number: 248-196-9 | CAS number: 27059-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on Daphnia magna aquatic invertebrates was predicted for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1). Effect concentration i.e EC50 value was estimated to be 245.92 mg/l for Daphnia magna for 48 hrs duration. It was concluded that the 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-4-1) was likely to be not toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Toxicity to aquatic algae and cyanobacteria
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity on algae was predicted for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1). Effect concentration i.e EC50 value was estimated to be 430.03 mg/l for Desmodesmus subspicatus for 72 hrs duration. It was concluded that the 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1) was likely to be not-toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Additional information
Short-term toxicity to aquatic invertebrates
Four studies including predicted data from validated tools and experimental data from peer reviewed journal and authorative database for short term aquatic invertebrate’s endpoint of test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (CAS: 27059-08-1) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on Daphnia magna aquatic invertebrates was predicted for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1). Effect concentration i.e EC50 value was estimated to be 245.92 mg/l for Daphnia magna for 48 hrs duration.
Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 553.12 mg/l for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate in 48 hrs.
Above both predicted results of target assist by experimental result of read across chemical Propyl acetate (Cas no. 109-60-4) from peer reviewed journal Gas Wasserfach Wasser Abwasser; 1981 which suggests the Effective concentration to 50% of Daphnia magna is 318 mg/L at 24 hrs, the Behavior (Equilibrium) effects were measured. It can be concluded that the Propyl acetate is not toxic to aquatic environment.
One another read across N-butyl acetate (Cas no.123-86-4) from same peer reviewed journal Gas Wasserfach Wasser Abwasser; 1981 which suggestsEffective concentration to 50% of Daphnia magna is 205 mg/L at 24 hrs, the Behavior (Equilibrium) effects were measured. It can be concluded that the N-butyl acetate is not toxic to aquatic environment.
Thus based on the all available effect concentrations which is in the range of 205 mg/l to 553.12 mg/l for target and read across chemicals which come to the conclusion that test substance 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1) was likely to be non-toxic to aquatic invertebrates at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP regulation.
Toxicity to aquatic algae and cyanobacteria
Four studies including predicted data from validated tools and experimental data from peer reviewed journal and authorative database for toxicity to aquatic algae endpoint of test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (CAS: 27059-08-1) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity on algae was predicted for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1). Effect concentration i.e EC50 value was estimated to be 430.03 mg/l for Desmodesmus subspicatus for 72 hrs duration.
Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the EC50 value for toxicity to aquatic algae was predicted. On the basis of EPI suite, ECOSAR version 1.1, the EC50 value for toxicity to aquatic algae was predicted to be 320.34 mg/l for 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate in 48 hrs.
Above both predicted results of target assist by experimental result of read across chemical Propyl acetate (Cas no. 109-60-4) from peer reviewed journal Environmental Science and Pollution Research; 2006 which suggests that No observable effect concentration for Scenedesmus subspicatus at (>=49 <=79) Minute(s) is 250 mg/L. On the basis of the value it can be concluded that the Propyl acetate is not toxic to aquatic environment.
One another read across Ethylene di(acetate (Cas no.111-55-7) from High Production Volume Information System data base; 2001 which suggestsThe 72hour NOEC for Ethylene di(acetate) was determined to be 119.86 mg/L (highest concentration tested). It can be concluded that the Ethylene di(acetate) is not toxic to aquatic environment.
Thus based on the all available effect concentrations which is in the range of 119.86 mg/l to 430.03 mg/l for target and read across chemicals which come to the conclusion that test substance 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (Cas no. 27059-08-1) was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP regulation.
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