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Diss Factsheets
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EC number: 232-245-6 | CAS number: 7791-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- basic data given, peer reviewed, documentation incomplete (method, clinical observations, hematology results, histopathology results described) Although the study documentation is incomplete, the results described are nevertheless reliable, as the data were produced and published by recognized institutions. Furthermore the results are plausible and in line with all other evidence regarding the chemical and biological properties, i.e. corrosivity, of sulfuryl chloride and its hydrolysis products hydrochloric acid, sulfuric acid, and chlorosulfonic acid.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute and subacute inhalation toxicity of sulfuryl chloride in rats.
- Author:
- Kelly, D.P. and Stula, E.F.
- Year:
- 1 983
- Bibliographic source:
- The Toxicologist Vol.3, No. 1, p.62
- Reference Type:
- secondary source
- Title:
- Sulfuryl chloride, CAS N° 7791-25-5, SIDS Initial Assessment Report
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP publications
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sulphuryl dichloride
- EC Number:
- 232-245-6
- EC Name:
- Sulphuryl dichloride
- Cas Number:
- 7791-25-5
- Molecular formula:
- Cl2O2S
- IUPAC Name:
- sulfuroyl dichloride
- Details on test material:
- - Name of test material (as cited in study report): Sulfuryl chloride as vapor
Purity: approx. 100 % (specially distilled batch)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 6 hours/day and 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 3, 10 or 30 [20] pmm (0, 17, 55, or 166 [110] mg/m3)(measured: 0,0; 3,1; 9,8; 22,3 ppm)
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: up to 2 weeks
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- CLINICAL SIGNS AND MORTALITY: The highest exposure concentration (30 ppm) was reduced to 20 ppm after 2 exposures due to excessive weight loss and terminated after 8 exposures due to the death of 2 rats. No mortalities in other exposure groups.
Clinical signs: labored breathing, red discharge from nose, swollen nose, reduced body temperature
BODY WEIGHT AND WEIGHT GAIN: excessive weight loss after 30 ppm, reduced body weight at low and mid dose levels; normal weight gain during reovery
HAEMATOLOGY: Immediately after exposure there was a dose-dependent increase in blood RBC's, hematocrit, and haemoglobin levels in the mid and high dose groups; WBC and neutrophils increased after the high dose
CLINICAL CHEMISTRY: increased blood urea nitrogen in all treated groups; increased chloesterol in mid and high dose groups
ORGAN WEIGHTS: Immediately after exposure there was a dose-dependent increase in lung-to-body weight ratio in the mid and high dose groups.
GROSS PATHOLOGY: lungs not collapsed in mid and high dose animals
HISTOPATHOLOGY: NON-NEOPLASTIC: Mid and high dosed rats showed a fibrino-necrotic bronchopneumonia; in addition, the high-level rats showed a fibrino-purulent rhinitis. lympgoid atrophy in thymus, In the 3 ppm group the only effects were an apparent exacerbation of naturally occurring murine pneumonitis.
OTHER FINDINGS: There was marked recovery from these lesions and a return to normal weight-gains two weeks later. There was a decrease of monocytes in all treated groups at the end of the recovery period.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 17 mg/m³ air
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There was marked recovery from these lesions and a return to normal weight-gains two weeks later. There was a decrease of monocytes in all treated groups at the end of the recovery period.
Statistical results: no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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