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EC number: 281-619-5 | CAS number: 84000-63-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from review article and safety assessment report
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Ethylenebis(tetrabromophthalimide) [CASRN 32588-76-4] Review of Toxicological Literature
- Author:
- NTP; National Institute of Environmental Health Sciences
- Year:
- 1 999
- Bibliographic source:
- NTP; National Institute of Environmental Health Sciences; October 1999
- Reference Type:
- secondary source
- Title:
- PRIMARY SKIN IRRITATION STUDY- RABBITS WITH COVER LETTER DATED 030890
- Author:
- NTRL REPORT
- Year:
- 1 990
- Bibliographic source:
- NTRL REPORT - OTS0522918; 13 MARCH 1990
Materials and methods
- Principles of method if other than guideline:
- The dermal irritation study of Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was conducted on albino rabbits to determine the degree of irritation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2'-ethane-1,2-diylbis(4,5,6,7-tetrabromo-1H-isoindole-1,3(2H)-dione)
- Cas Number:
- 32588-76-4
- Molecular formula:
- C18H4Br8N2O4
- IUPAC Name:
- 2,2'-ethane-1,2-diylbis(4,5,6,7-tetrabromo-1H-isoindole-1,3(2H)-dione)
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Ethylene bis(tetrabromophthalimide)
- Molecular formula): C18H4Br8N2O4
- Molecular weight: 951.472 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles:c12c(C(=O)N(C1=O)CCN1C(c3c(c(Br)c(c(c3C1=O)Br)Br)Br)=O)c(c(Br)c(c2Br)Br)Br
-InChI:1S/C18H4Br8N2O4/c19-7-3-4(8(20)12(24)11(7)23)16(30)27(15(3)29)1-2-28-17(31)5-6(18(28)32)10(22)14(26)13(25)9(5)21/h1-2H2
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Ethylene bis(tetrabromophthalimide)
- Molecular formula): C18H4Br8N2O4
- Molecular weight: 951.472 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles:c12c(C(=O)N(C1=O)CCN1C(c3c(c(Br)c(c(c3C1=O)Br)Br)Br)=O)c(c(Br)c(c2Br)Br)Br
-InChI:1S/C18H4Br8N2O4/c19-7-3-4(8(20)12(24)11(7)23)16(30)27(15(3)29)1-2-28-17(31)5-6(18(28)32)10(22)14(26)13(25)9(5)21/h1-2H2
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Remarks:
- intact and abraded site
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- 6
- Details on study design:
- - Area of exposure: the trunk of the animal
- Type of wrap if used: The sites were covered with gauze pads and an impervious material was wrapped around the trunk of the animal to hold the pads in place
SCORING SYSTEM: The Draize method
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No erythema, eschar, or edema formation occurred at 24 or 72 hours.
Any other information on results incl. tables
Table: 1:Primary skin irritation |
||||||||
Erythema and eschar formation |
Reading (Hours) |
Rabbit number |
Average |
|||||
1 |
2 |
3 |
4 |
5 |
6 |
|||
Intact skin |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Intact skin |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Abraded skin |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Abraded skin |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Subtotal |
0.00 |
|||||||
Edema formation |
|
|
|
|
|
|
|
|
Intact skin |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Intact skin |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Abraded skin |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Abraded skin |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
Subtotal |
0.00 |
|||||||
Total |
0.00 |
|||||||
PRIMARY IRRITATION SCORE: 0 |
|
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was considered to be not irritating to the skin of albino rabbits.
- Executive summary:
The dermal irritation study of Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was conducted on albino rabbits to determine the degree of irritation.
In this study, 500 mg of Ethylenebis(tetrabromophthalimide) was applied to the abraded skin of three rabbits and the intact skin of the other three over the wide shaved area. One side of each rabbit’s back was slightly abraded at one site with a lancet sufficiently deep to penetrate the stratum corneum but not to enter the derma and produce bleeding. The other side of the back was left intact.
The sites were covered with gauze pads and an impervious material was wrapped around the trunk of the animal to hold the pads in place. The dressing was removed at 24 hours and 72 hours in order to observe the sites.the skin reactions were observed according toDraize method.
None of the treated rabbit produced erythema, eschar, or edema at 24 or 72 hours with primary irritation index of 0. Hence the chemical Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4)was considered to be not irritating to the skin of albino rabbits.
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