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EC number: 212-842-8 | CAS number: 873-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial Submission: Oral LD50 Test of Methanol, Sodium Salt in Rats with Cover Letter Dated 08/10/92
- Author:
- E I Dupont DE Nemours & CO
- Year:
- 1 992
- Bibliographic source:
- OTS0555267, Haskell Laboratory, 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study of Methanol, sodium salt in rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methanol, sodium salt
- Cas Number:
- 124-41-4
- Molecular formula:
- CH4O.Na
- IUPAC Name:
- Methanol, sodium salt
- Details on test material:
- - Name of test material (as cited in study report): Methanol, sodium salt
- Molecular formula (if other than submission substance): CH4O.Na
- Molecular weight (if other than submission substance): 54.0237 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methanol, sodium salt
- Molecular formula (if other than submission substance): CH4O.Na
- Molecular weight (if other than submission substance): 54.0237 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- other: Crl: CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1500, 1800, 2250, 2380, 2600 and 3400 mg/kg bw
- Amount of vehicle (if gavage): 2-3 ml
- Justification for choice of vehicle: corn oil
DOSAGE PREPARATION (if unusual): Methanol, sodium salt administrated as a suspension in corn oil - Doses:
- 1500, 1800, 2250, 2380, 2600 and 3400 mg/kg bw
- No. of animals per sex per dose:
- Total : 60
1500 mg/kg bw: 10 male rat
1800 mg/kg bw: 10 male rat
2250 mg/kg bw: 10 male rat
2380 mg/kg bw: 10 male rat
2600 mg/kg bw: 10 male rat
3400 mg/kg bw: 10 male rat - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Yes
- Necropsy of survivors performed: yes
- Other examinations performed: Mortality, clinical signs and body weight were examined. - Statistics:
- LD50 value was calculated from the mortality data using the method of D. J. Finney.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 037 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- When treated with 2,600 and 3,400 mg/kg bw, all animals died.
When treated with 2380 mg/kg bw, 8 animals died.
When treated with 2,250 mg/kg bw, 2 animals died.
When treated with 1,800 mg/kg bw, 5 animals died.
When treated with 1,500 mg/kg bw, 1 animals died.
Deaths occurred up to 14 day after dosing. - Clinical signs:
- other: Laborad breathing, weakness and wet and stained perineal area were observed in all treated rats. When treated with 1,800 to 3,400 mg/kg bw, Salivation and lethargy were observed in treated rats. When treated with 2380 to 2600 mg/kg bw, ataxia were obs
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
Dose (mg/kg) |
Average Body Weight (g) |
Suspension (%) |
Average dose (mL) |
Mortality ratio |
LD50 |
3,400 |
238 |
30 |
2.70 |
10/10 |
2037 mg/kg |
2,600 |
244 |
30 |
2.11 |
10/10 |
|
2.380 |
2'2 |
30 |
2.00 |
8/10 |
|
2,250 |
241 |
20 |
2.72 |
2/10 |
|
1.800 |
248 |
20 |
2.23 |
5/10 |
|
1.500 |
243 |
20 |
1.83 |
1/10 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 2037 mg/kg bw when Crl: CD male rats were treated with Methanol, sodium salt orally by gavage.
- Executive summary:
In a acute oral toxicity study,Crl: CDmale rats were treated withMethanol, sodium salt in the concentration of1500, 1800, 2250, 2380, 2600 and 3400 mg/kg bw in corn oilorally by gavage. All animals died at 2,600 and 3,400 mg/kg bw, 8 animals died at 2380 mg/kg bw, 2 animals died at 2,250 mg/kg bw, 5 animals died at 1,800 mg/kg bw and 1 animals died at 1,500 mg/kg bw. Deaths occurred up to 14 day after dosing. Laborad breathing, weakness and wet and stained perineal area were observed in all treated rats. Salivation and lethargywere observed in treated rats at 1,800 to 3,400 mg/kg bw, ataxiaat 2380 to 2600 mg/kg bw,Stained face at 1800, 2380, 2600 and 3400 mg/kg bw, Lacrimation at 2600 and 3400 mg/kg bw, pallor at 2600 mg/kg bw,Chromodacryorrhea and ruffled fur at 1500 to 2600 mg/kg, Diarrhea and congestion at 1500 to 2380 mg/kg, Priapism at 1800 to 2600 mg/kg and gasping was observed in treated rat at 1500, 1600 to 3400 mg/kg. Weight loss for 9-14 days after dosing was observed in treated rats. Therefore,LD50 was considered to be 2037 mg/kg bw whenCrl: CDmale rats were treated withMethanol, sodium salt orally by gavage.
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